ID A0A0A3IMY6_9BACI Unreviewed; 867 AA.
AC A0A0A3IMY6;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=CD32_10080 {ECO:0000313|EMBL:KGR84800.1};
OS Lysinibacillus odysseyi 34hs-1 = NBRC 100172.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX NCBI_TaxID=1220589 {ECO:0000313|EMBL:KGR84800.1, ECO:0000313|Proteomes:UP000030437};
RN [1] {ECO:0000313|EMBL:KGR84800.1, ECO:0000313|Proteomes:UP000030437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 100172 {ECO:0000313|EMBL:KGR84800.1,
RC ECO:0000313|Proteomes:UP000030437};
RA Zhang F., Wang G., Zhang L.;
RT "Draft genome sequence of Lysinibacillus odysseyi NBRC 100172.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGR84800.1}.
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DR EMBL; JPVP01000055; KGR84800.1; -; Genomic_DNA.
DR RefSeq; WP_036154150.1; NZ_JPVP01000055.1.
DR AlphaFoldDB; A0A0A3IMY6; -.
DR STRING; 1220589.CD32_10080; -.
DR eggNOG; COG0249; Bacteria.
DR Proteomes; UP000030437; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000030437}.
FT DOMAIN 677..693
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 603..610
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 867 AA; 97644 MW; 770DC126662FCA95 CRC64;
MYTPMMQQYL LIKEDYKDAF LFFRLGDFYE MFFDDAVKAS QILEITLTGR EAGGKERIPM
CGVPYHSAKN YIETLVSKGY KVAICEQTED PKQAKGVVKR EVVQLITPGT ITEGKTIDSK
TNHFLACAER MNENELAFAY LDVSTGEAHA QIIEGGVKEC IQQLQSLAIR EVITAEGLQL
EMAELAGAAG IVISLEQEEI GVHTVEVYLK DVPEQVKPAA RRLLQYVERT QMRSLSHLQA
FTYTETKQFL RIDTNSKRNL ELIQSIRGGD QKGTLLWLLD ETVTAMGGRK LKQWLHQPLA
TRGAIEARLA IVTDLLEEFF LRGELRDLLK SVYDLERLAG RVAFGNVGGR DLAQLRESLR
QVPAIKAQLL ESGKETLENV GHALDTCEDI EALLARAITD HPPIAIKEGD VIRDGYNERL
DELRYAARNG KDWIMQLEQK ERQLTGINNL KIGYNRIFGY YIEITKSHIG KADLTRYERK
QTLANCERYI TDELKEKESL ILNAEEESLA LEYDLFLKLR EELKAYIPRV QSLAAAISEL
DVFMSFAVVT EKYRFTKPVF HEGRSLKIME GRHPVVEKML GKQMYVPNDC ILPEEKNMML
ITGPNMSGKS TYMRQVALIV ILAQMGCYVP AAEAELPITD QIFTRIGAAD DLAAGQSTFM
VEMMESQHAI THATKNSLLL FDEIGRGTST YDGMSLAQAM MEYIHTEIGA NTLFSTHYHE
LTQLEEQLVR LKNVHVAATE QNGRVVFLHK VKDGAADKSY GVHVAELAEM PAPIIERARI
LLEQFEAQDK PCAASAAAET IIVPEPSVEP VQKEEDLQLS LFAPVDEVSP EEKEVLEALE
KCNVMGTTPM QAMTLLYELQ QKLVNKK
//
