ID A0A0A3IS28_9BACI Unreviewed; 191 AA.
AC A0A0A3IS28;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Transcription factor FapR {ECO:0000256|HAMAP-Rule:MF_01814};
DE AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000256|HAMAP-Rule:MF_01814};
GN Name=fapR {ECO:0000256|HAMAP-Rule:MF_01814};
GN ORFNames=CD32_03235 {ECO:0000313|EMBL:KGR87579.1};
OS Lysinibacillus odysseyi 34hs-1 = NBRC 100172.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX NCBI_TaxID=1220589 {ECO:0000313|EMBL:KGR87579.1, ECO:0000313|Proteomes:UP000030437};
RN [1] {ECO:0000313|EMBL:KGR87579.1, ECO:0000313|Proteomes:UP000030437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 100172 {ECO:0000313|EMBL:KGR87579.1,
RC ECO:0000313|Proteomes:UP000030437};
RA Zhang F., Wang G., Zhang L.;
RT "Draft genome sequence of Lysinibacillus odysseyi NBRC 100172.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC lipid biosynthesis by repressing genes involved in fatty acid and
CC phospholipid metabolism. {ECO:0000256|HAMAP-Rule:MF_01814}.
CC -!- SIMILARITY: Belongs to the FapR family. {ECO:0000256|HAMAP-
CC Rule:MF_01814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGR87579.1}.
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DR EMBL; JPVP01000046; KGR87579.1; -; Genomic_DNA.
DR RefSeq; WP_036151168.1; NZ_JPVP01000046.1.
DR AlphaFoldDB; A0A0A3IS28; -.
DR STRING; 1220589.CD32_03235; -.
DR eggNOG; COG1349; Bacteria.
DR OrthoDB; 1706183at2; -.
DR Proteomes; UP000030437; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR InterPro; IPR001034; DeoR_HTH.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR017275; Transcription_factor_FapR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF08220; HTH_DeoR; 1.
DR PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01814};
KW Fatty acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01814};
KW Fatty acid metabolism {ECO:0000256|HAMAP-Rule:MF_01814};
KW Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01814};
KW Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_01814};
KW Reference proteome {ECO:0000313|Proteomes:UP000030437};
KW Repressor {ECO:0000256|HAMAP-Rule:MF_01814};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_01814};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_01814}.
FT DOMAIN 8..48
FT /note="HTH deoR-type"
FT /evidence="ECO:0000259|Pfam:PF08220"
SQ SEQUENCE 191 AA; 21645 MW; F49F77A2435DA432 CRC64;
MKRTKKERQQ LLTETIADNP FVTDEQLAHQ FGVSVQTIRL DRMELSIPEL RERIKDVASK
NYENEVKSLP LDEVIGEIID IELDKRALSI FDVGEEHVFQ RNNIARGHHL FAQANSLAVA
VIDDELALTV KSNVAFVKPV KAGDRVVTKA IVRTQHTEKN RTIIDVTSTV NNEVVFTGEF
EMYRTKGGNE T
//
