ID A0A0A5GP04_9BACI Unreviewed; 374 AA.
AC A0A0A5GP04;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:KGX92963.1};
GN ORFNames=N781_13895 {ECO:0000313|EMBL:KGX92963.1};
OS Pontibacillus halophilus JSM 076056 = DSM 19796.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Pontibacillus.
OX NCBI_TaxID=1385510 {ECO:0000313|EMBL:KGX92963.1, ECO:0000313|Proteomes:UP000030528};
RN [1] {ECO:0000313|EMBL:KGX92963.1, ECO:0000313|Proteomes:UP000030528}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JSM 076056 {ECO:0000313|EMBL:KGX92963.1,
RC ECO:0000313|Proteomes:UP000030528};
RA Huang J., Wang G.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGX92963.1}.
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DR EMBL; AVPE01000004; KGX92963.1; -; Genomic_DNA.
DR RefSeq; WP_026800042.1; NZ_AVPE01000004.1.
DR AlphaFoldDB; A0A0A5GP04; -.
DR STRING; 1385510.GCA_000425205_01610; -.
DR eggNOG; COG0626; Bacteria.
DR OrthoDB; 9803887at2; -.
DR Proteomes; UP000030528; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 2.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF91; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000030528}.
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 198
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 374 AA; 41292 MW; A62B5AD48C572F17 CRC64;
MSNHHILTKL AQTGNRSETT TGAVNPPIYL STAYRHEGIG QSTGYDYTRT GNPTRAVLEQ
SIADLEGGES GFAFSSGMAA IQATFGLFEP GDEFIVTQDV YGGSYRLFEN QLKKSGLSFN
YVNSSNPKDF EQAITDKTKG FFIETPTNPL MTEIDVQQMS EIAAEHELLL IVDNTFYTPY
LQRPIELGAD LVIHSATKYL GGHNDVLAGL VVSRHEALSE QLASEQNATG AVLSPFDCWL
LMRGMKTLGL RMSQHEENAK LVAAFLEHNP YVTDVLYPGQ GGMLSFRVES EEAIPILLES
FRLISFAESL GGTETFITYP ATQTHMDIPE EIRSNYGVCN RLLRLSVGLE YSEDLMKDLK
EALEAAHKGV EVHE
//
