ID A0A0A5HPP0_9BACI Unreviewed; 275 AA.
AC A0A0A5HPP0;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Glyoxal reductase {ECO:0000313|EMBL:KGX85582.1};
GN ORFNames=N784_08720 {ECO:0000313|EMBL:KGX85582.1};
OS Pontibacillus litoralis JSM 072002.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Pontibacillus.
OX NCBI_TaxID=1385512 {ECO:0000313|EMBL:KGX85582.1, ECO:0000313|Proteomes:UP000030401};
RN [1] {ECO:0000313|EMBL:KGX85582.1, ECO:0000313|Proteomes:UP000030401}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JSM 072002 {ECO:0000313|EMBL:KGX85582.1,
RC ECO:0000313|Proteomes:UP000030401};
RA Huang J., Wang G.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGX85582.1}.
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DR EMBL; AVPG01000021; KGX85582.1; -; Genomic_DNA.
DR RefSeq; WP_036835325.1; NZ_AVPG01000021.1.
DR AlphaFoldDB; A0A0A5HPP0; -.
DR SMR; A0A0A5HPP0; -.
DR STRING; 1385512.N784_08720; -.
DR eggNOG; COG0656; Bacteria.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000030401; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19157; AKR_AKR5G1-3; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044500; AKR5G.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030401}.
FT DOMAIN 19..261
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 53
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 111
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 78
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 275 AA; 31396 MW; 657553B233155D7B CRC64;
MSHLQDTISL HNGVQMPRLG LGVFKVEDGE EVIHSVKTAL AHGYRSIDTA AVYQNEEGVG
QAIRESGIAR EELFVTSKLW NADQGYESAL QAFETTMDKL GLEYLDLYLI HWPVEGKYKD
SWRALERLYQ EGKIRAIGVS NFQVHHLEDI VNDASVKPMV NQIELHPKLT QQQVRSYCQE
QNIIVEAWSP LMQGEILQEP LIKELAQKYE KSPAQIVIRW DLQIGIVTIP KSTKTHRIHE
NADVYDFTLT EEEVASISAL NEDHRVGPHP DHFDF
//
