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Database: UniProt
Entry: A0A0A5HSH6_9VIBR
LinkDB: A0A0A5HSH6_9VIBR
Original site: A0A0A5HSH6_9VIBR 
ID   A0A0A5HSH6_9VIBR        Unreviewed;       429 AA.
AC   A0A0A5HSH6;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   05-JUN-2019, entry version 31.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=NM06_18010 {ECO:0000313|EMBL:KGY07265.1};
OS   Vibrio sinaloensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio; Vibrio oreintalis group.
OX   NCBI_TaxID=379097 {ECO:0000313|EMBL:KGY07265.1, ECO:0000313|Proteomes:UP000030451};
RN   [1] {ECO:0000313|EMBL:KGY07265.1, ECO:0000313|Proteomes:UP000030451}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T08 {ECO:0000313|EMBL:KGY07265.1,
RC   ECO:0000313|Proteomes:UP000030451};
RA   Chan K.-G., Mohamad N.I.;
RT   "Genome sequencing of Vibrio sinaloensis T08.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KGY07265.1}.
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DR   EMBL; JRWP01000050; KGY07265.1; -; Genomic_DNA.
DR   RefSeq; WP_038192696.1; NZ_JRWP01000050.1.
DR   EnsemblBacteria; KGY07265; KGY07265; NM06_18010.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000030451; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030451};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:KGY07265.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138}.
FT   DOMAIN      109    316       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   REGION      212    235       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0A5HSH6}.
SQ   SEQUENCE   429 AA;  45507 MW;  0A6AAFA218E83FC7 CRC64;
     MNVLIIGAGG REHALGWKAA QNPNVETVFV APGNAGTALE PKLENVNIGV EAISELVSFA
     QEKKIELTIV GPEAPLVIGV VDAFREAGLP IFGPTEAAAQ LEGSKAFTKD FLARHNIPTA
     AYANFTEIEP ALAYVREQGA PIVVKADGLA AGKGVIVAMT LEEAEDAIKD MLAGNAFGEA
     GSRVVIEEFL EGEEASFIVM VDGKSVLPMA TSQDHKRVGD KDTGPNTGGM GAYSPAPVVT
     PEIHERILEE VIYPTVRGMD AEGAPYTGFL YAGLMIDKDG TPKVIEYNCR FGDPETQPIM
     MRMESDLVEL CLMAINEKLD EAESKWDPRA SIGVVLAAGG YPADYAKGDV ISLPAAEAEG
     EKIFHAGTAN NAAGEVVTNG GRVLCATALG NSVSEAQERA YALAKQVSWN GMFHRNDIGY
     RAIAREQEK
//
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