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Database: UniProt
Entry: A0A0A6D0Z5_9SPHN
LinkDB: A0A0A6D0Z5_9SPHN
Original site: A0A0A6D0Z5_9SPHN 
ID   A0A0A6D0Z5_9SPHN        Unreviewed;       676 AA.
AC   A0A0A6D0Z5;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KHA65546.1};
GN   ORFNames=NI18_01165 {ECO:0000313|EMBL:KHA65546.1};
OS   Sphingomonas sp. Ant20.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=104605 {ECO:0000313|EMBL:KHA65546.1, ECO:0000313|Proteomes:UP000033201};
RN   [1] {ECO:0000313|EMBL:KHA65546.1, ECO:0000313|Proteomes:UP000033201}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ant20 {ECO:0000313|EMBL:KHA65546.1,
RC   ECO:0000313|Proteomes:UP000033201};
RA   Ronca S., Frossard A., Guerrero L.D., Makhalanyane T.P., Aislabie J.M.,
RA   Cowan D.A.;
RT   "Draft Genome Sequence of Spingomonas sp. strain Ant20, isolated from oil-
RT   polluted soil near Scott Base, Antarctica.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHA65546.1}.
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DR   EMBL; JRVI01000004; KHA65546.1; -; Genomic_DNA.
DR   RefSeq; WP_037527504.1; NZ_JRVI01000004.1.
DR   AlphaFoldDB; A0A0A6D0Z5; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000033201; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR   PANTHER; PTHR23309:SF49; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033201}.
FT   DOMAIN          295..470
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          475..559
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   676 AA;  72416 MW;  C043D5E869B80543 CRC64;
     MTTPIRTERH DDVLVIISNN PPVNALGAAV RQGLEAAIKD GVADASITAM VIRCDGRTFF
     AGADITEFGK PMVEPGLPTV VDMIEASSKP VVAAIHGTAL GGGCEVTLGC HYRVAVPSAK
     IGTPEVKLGL LPGAGGTQRI PRIAGVKLAL EMTAKGDPIS AKKALDAGLI DKIVGEDSLE
     ADAIAFAREI AAKRPLPRAS EKTAQADPDA VAAFKKENAR RFRNFDAPAA NIACVEKAAD
     GSSFAEGVAF EREQFMALMM GVQSAAQRHI FFAERQAAKI DDVPADTKLR EIKRVGVIGA
     GTMGGGIAMN FLSAGIPVTI VEMQQDALDR GTGVVRKNYE ATAAKGRMKP EQVEQAMGAL
     KPTLDFADLA ECDLIIEAVY ETMEVKKDIF TKLDAIAKPG AILASNTSYL NIDEIAACTK
     RPEDVVGMHF FSPANVMKLL EVVRGDKTAD DVLATVMALA KKIRKVAVVA GVTYGFIGNR
     MLMPRQVEAT KLLLEGASPE QIDRVHVAFG MPMGPFQMSD LAGVDIGWHR DPSRIENIRD
     ALAAENRWGQ KTKAGFYDYD EKRTPSNSPR VAEIIDDFRA KSGVTPREIS DEEIVARTLY
     TMVNEGALIL EEGKAQRASD VDVVWIYGYG WPVYRGGPMF WAQSEGLPKV VAGLEKYGFP
     VAKSLKDAAA SGGKIK
//
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