ID A0A0A6P0V5_9GAMM Unreviewed; 509 AA.
AC A0A0A6P0V5;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Radical SAM domain-containing protein {ECO:0000313|EMBL:OAD21956.1};
GN ORFNames=THIOM_002261 {ECO:0000313|EMBL:OAD21956.1};
OS Candidatus Thiomargarita nelsonii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Thiotrichaceae; Thiomargarita.
OX NCBI_TaxID=1003181 {ECO:0000313|EMBL:OAD21956.1, ECO:0000313|Proteomes:UP000076962};
RN [1] {ECO:0000313|EMBL:OAD21956.1, ECO:0000313|Proteomes:UP000076962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=THI036 {ECO:0000313|EMBL:OAD21956.1,
RC ECO:0000313|Proteomes:UP000076962};
RA Winkel M., Salman V., Woyke T., Schulz-Vogt H., Richter M., Flood B.,
RA Bailey J., Amann R., Mussmann M.;
RT "Single-cell genome of chain-forming Candidatus Thiomargarita nelsonii and
RT comparison to other large sulfur-oxidizing bacteria.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAD21956.1}.
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DR EMBL; LUTY01001270; OAD21956.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A6P0V5; -.
DR Proteomes; UP000076962; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT DOMAIN 10..150
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 234..460
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 509 AA; 58341 MW; 2F68B2F0888D2D19 CRC64;
MKVFFIVPPE LHFIEAYNTK KVDKGREFRQ KLGILAVAGY LRDVGGITPR IIDSLADMLS
LEDIRKILKK EQPDIVGFSV LTFNILDCLE VVRIISEVSP ATKVCFGGFH PTIYPLETLS
LPGVDFIVMG EGEITFTELV LTLKDSPHAK NKEPGNLKEL GGETNKNKTI PILDLTDSST
EKKKGFAAID GLGWKDQKGR PILNAPRKPV AKLDTFPMPA HDLIDLEKYS LVLAEDAKVA
SIQTSRGCPS KCTFCDIRLT RYRYRSAEHV MEEIKFLTGL GIREFFFLDD TFTINKKRVY
ELCNLLIESK LDIKYKISSR VDRVNQEMLD MLAASGCYRI HYGVETGSQR LLDYLEKGVT
LEQTINAFKM TKKAGIETFA YMMIGIPTET KDDIEQTIQF VNKLQPDRVN YSICSPFPKT
KLYETALNND PTMEDYWGEF AKNPEPNFKI RTLNEYFTQE ELRNIQDKAL KRFYFSPRQL
AREIYHTRSF KQLLLKAKFG MRFLSPRFK
//