ID   A0A0A6UKX4_ACTUT        Unreviewed;       797 AA.
AC   A0A0A6UKX4;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:KHD76096.1};
GN   ORFNames=MB27_19470 {ECO:0000313|EMBL:KHD76096.1};
OS   Actinoplanes utahensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=1869 {ECO:0000313|EMBL:KHD76096.1, ECO:0000313|Proteomes:UP000054537};
RN   [1] {ECO:0000313|EMBL:KHD76096.1, ECO:0000313|Proteomes:UP000054537}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 12052 {ECO:0000313|EMBL:KHD76096.1,
RC   ECO:0000313|Proteomes:UP000054537};
RA   Velasco-Bucheli B., del Cerro C., Hormigo D., Garcia J.L., Acebal C.,
RA   Arroyo M., de la Mata I.;
RT   "Draft genome sequence of Actinoplanes utahensis NRRL 12052.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHD76096.1}.
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DR   EMBL; JRTT01000021; KHD76096.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A6UKX4; -.
DR   STRING; 1869.MB27_19470; -.
DR   eggNOG; COG0658; Bacteria.
DR   eggNOG; COG2333; Bacteria.
DR   Proteomes; UP000054537; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054537};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        268..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        341..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        429..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        483..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        518..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          244..507
FT                   /note="ComEC/Rec2-related protein"
FT                   /evidence="ECO:0000259|Pfam:PF03772"
FT   DOMAIN          550..741
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|Pfam:PF00753"
SQ   SEQUENCE   797 AA;  80056 MW;  7BEDC2D66C732A90 CRC64;
     MPDLRLAGFT VGLWLAALGT LHLSAVWGIA VGAAGLAVAA VTAAAGFAGR APGSRRGGTA
     RGGGEARAAG EAGWGGAVRW IVAAVALGVG CGAIATGARM SVREAPVLRA LVESGATVRV
     ELVVRDDPRP LARSAGPPTY LVAVELESVT AEDAAPIRLT ARALVLGSDP GWRELLPGQR
     ATATGRLMPP RPGDLRAAVL SARTPPRLEG RPSWVQRGAG VLRAGLQRAC EPLPDDSGGL
     LPGLVVGDTS RLDPALEADF RTTGMTHLTA VSGTNVAIVL GLVLFVVRRT RAGPLLCAVL
     CAIALAGFVI LARPSPSVIR AAAMGAIGLL GLAAGRPRAA VPALAAGAAV LLIADPELAA
     DPGFALSVLA TAGLLLIAPV WRDGLQRRGW PGWVAEALAV PAAAQVACGP VVAAISATVS
     LVAVPANLLA VPAIAPATLF GVAAAVLSPV WPAGAEFAAW IGHWPTEWLV LVARTGARIP
     AGALPWPGGA VGGVLLAVLT VAFLVAARRE PVRRLATVVA LGAVLGALPV RLLASGWPPP
     GWLVVACAVG QGDAVVLPAG SGRAVVVDAG PEPDAVDRCL RRLGIRHVVV LVVSHFHADH
     VGGVAGVFRD REVDAVIGPD WPEPAAGRAS VAESAAGAGI AVQAAGAGWA YTAGGLRLEV
     IGPLSPMRGT NSDPNNNSLI LRAVLGGRSV LLLGDAETEE QEDLVAGIGA AGLRADVLKV
     AHHGSALQSP ALVEAVDPTV ALVSVGRDND YGHPNAVLLG WIAQGGARIL RTDESGDVAA
     VAVDGGLAVA ARGDPPQ
//