ID A0A0A6UPR3_ACTUT Unreviewed; 257 AA.
AC A0A0A6UPR3;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=tRNA(His) guanylyltransferase {ECO:0000256|ARBA:ARBA00012511};
DE EC=2.7.7.79 {ECO:0000256|ARBA:ARBA00012511};
GN ORFNames=MB27_06620 {ECO:0000313|EMBL:KHD78135.1};
OS Actinoplanes utahensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1869 {ECO:0000313|EMBL:KHD78135.1, ECO:0000313|Proteomes:UP000054537};
RN [1] {ECO:0000313|EMBL:KHD78135.1, ECO:0000313|Proteomes:UP000054537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 12052 {ECO:0000313|EMBL:KHD78135.1,
RC ECO:0000313|Proteomes:UP000054537};
RA Velasco-Bucheli B., del Cerro C., Hormigo D., Garcia J.L., Acebal C.,
RA Arroyo M., de la Mata I.;
RT "Draft genome sequence of Actinoplanes utahensis NRRL 12052.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the tRNA(His) guanylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010113}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHD78135.1}.
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DR EMBL; JRTT01000006; KHD78135.1; -; Genomic_DNA.
DR RefSeq; WP_043523220.1; NZ_JRTT01000006.1.
DR AlphaFoldDB; A0A0A6UPR3; -.
DR STRING; 1869.MB27_06620; -.
DR eggNOG; COG4021; Bacteria.
DR OrthoDB; 4547336at2; -.
DR Proteomes; UP000054537; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0008193; F:tRNA guanylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006400; P:tRNA modification; IEA:InterPro.
DR Gene3D; 3.30.70.3000; -; 1.
DR InterPro; IPR025845; Thg1_C_dom.
DR InterPro; IPR024956; tRNAHis_GuaTrfase_cat.
DR InterPro; IPR007537; tRNAHis_GuaTrfase_Thg1.
DR InterPro; IPR038469; tRNAHis_GuaTrfase_Thg1_sf.
DR PANTHER; PTHR12729:SF6; TRNA(HIS) GUANYLYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR12729; UNCHARACTERIZED; 1.
DR Pfam; PF04446; Thg1; 1.
DR Pfam; PF14413; Thg1C; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:KHD78135.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054537};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KHD78135.1};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 10..120
FT /note="tRNAHis guanylyltransferase catalytic"
FT /evidence="ECO:0000259|Pfam:PF04446"
FT DOMAIN 130..208
FT /note="Thg1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14413"
SQ SEQUENCE 257 AA; 28953 MW; A0B4E32C09870D41 CRC64;
METFEARQRS REYFHALTVL PGVWTVLRLD GRGFSRFTEQ HFSKPFDERF AEHMTVAAET
LLVEMGARYA YTVSDEISLL FAPGFELFGR SVEKLVSVSA GIGSAAFTRA AGTAAHFDSR
LWLGATVGDV VDYFSWRQSD AARSALNGWC YWTLRAAGRT RQEAADAIEG ASTAGKNDLL
YRHGINFNEV PSWQRRGIGL WWETYQRSGH DPIRGIDVTA DRRRIHIERS LPMKDTYRDL
VEQLTGSPVS TGQHCHG
//
