ID A0A0A6XCX4_ACTUT Unreviewed; 802 AA.
AC A0A0A6XCX4;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Penicillin amidase {ECO:0008006|Google:ProtNLM};
GN ORFNames=MB27_09015 {ECO:0000313|EMBL:KHD77917.1};
OS Actinoplanes utahensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1869 {ECO:0000313|EMBL:KHD77917.1, ECO:0000313|Proteomes:UP000054537};
RN [1] {ECO:0000313|EMBL:KHD77917.1, ECO:0000313|Proteomes:UP000054537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 12052 {ECO:0000313|EMBL:KHD77917.1,
RC ECO:0000313|Proteomes:UP000054537};
RA Velasco-Bucheli B., del Cerro C., Hormigo D., Garcia J.L., Acebal C.,
RA Arroyo M., de la Mata I.;
RT "Draft genome sequence of Actinoplanes utahensis NRRL 12052.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S45 family.
CC {ECO:0000256|ARBA:ARBA00006586}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHD77917.1}.
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DR EMBL; JRTT01000008; KHD77917.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A6XCX4; -.
DR STRING; 1869.MB27_09015; -.
DR MEROPS; S45.005; -.
DR eggNOG; COG2366; Bacteria.
DR Proteomes; UP000054537; Unassembled WGS sequence.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.1400.10; -; 1.
DR Gene3D; 2.30.120.10; -; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR Gene3D; 1.10.439.10; Penicillin Amidohydrolase, domain 1; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR043147; Penicillin_amidase_A-knob.
DR InterPro; IPR023343; Penicillin_amidase_dom1.
DR InterPro; IPR043146; Penicillin_amidase_N_B-knob.
DR InterPro; IPR002692; S45.
DR PANTHER; PTHR34218:SF3; ACYL-HOMOSERINE LACTONE ACYLASE PVDQ; 1.
DR PANTHER; PTHR34218; PEPTIDASE S45 PENICILLIN AMIDASE; 1.
DR Pfam; PF01804; Penicil_amidase; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000054537};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..802
FT /note="Penicillin amidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039024934"
SQ SEQUENCE 802 AA; 84210 MW; 7D539078DD34B5AA CRC64;
MPGRRLPAAA VLFLLAALPW VATPAAASGA DRPHAVVRYT EYGVPHILAA DHRGLGYGYG
YAVARDNICI LADSYVTVSA QRSLFHGPAA PTRSDFGRVT TALNSDLYFQ NLNDSGVVER
LMSLPAPLGP EREVTDMVRG YVTGYNRYLR DTGVDALTDP ACRGADWVRP ITELDVFRAM
HAFVIGSGSG SVIDGLVTPQ PPAGPVPPTA TPAVSAEQAR TVRDSGADRG SNAVAAGRDG
TSGARSVLLG NPHYGWSGVA RFWQSQLTIP GRLNVSGAGL LGFPAVLIGH NRDVAWSHTV
STPTTYGLFE LTTDPADPTR YLRDGVSTPM TSRTVTVRAK QADGSVTPVS RTLWSTELGP
VIGAIPGVTL PWGATVHVFR DANAGNLRML NTWFGFGAAR STSEVDQVLR RTQGVPWLNT
VASDRAGNAY YSGIQVVPHV TDERLAACST ALGQQLFRIN GTPVLDGSRA ACAWGTDPDA
VESGLFGPSR LPTLTRADYV ANANDSAWLT NPAQPLTGYP AVLGAAGTQR SARTQQTIVS
AQRRLAGADG LPGAGFSLDT MSRVLFSDDS RVAELTAADA AAMCAAFPDG VAAGAAGPVD
VTEACPVLAA WDRSFRLDSR GSLLFARFAT RLGAVPGGPW ATPFDPADPI GTPAGLATAK
PAVQRAFADA VAELRSAGIA LDAPLGDHQS VTRAGETIPV HGAPHALGVL NVITPTWRAG
AGNVDVVHGS SFIQVVEFGA TGAPRARTLL TYSQSADPTS PHHADQTRLF SRSTWVTSRF
TEREIAASPV LSQIRLTERA PR
//
