ID A0A0A7FZ77_9CLOT Unreviewed; 573 AA.
AC A0A0A7FZ77;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Na+/H+ antiporter family protein {ECO:0000313|EMBL:AIY84867.1};
GN ORFNames=U729_1214 {ECO:0000313|EMBL:AIY84867.1};
OS Clostridium baratii str. Sullivan.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1415775 {ECO:0000313|EMBL:AIY84867.1, ECO:0000313|Proteomes:UP000030635};
RN [1] {ECO:0000313|EMBL:AIY84867.1, ECO:0000313|Proteomes:UP000030635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sullivan {ECO:0000313|EMBL:AIY84867.1};
RX PubMed=25489752; DOI=10.1016/j.meegid.2014.12.002;
RA Smith T.J., Hill K.K., Xie G., Foley B.T., Williamson C.H., Foster J.T.,
RA Johnson S.L., Chertkov O., Teshima H., Gibbons H.S., Johnsky L.A.,
RA Karavis M.A., Smith L.A.;
RT "Genomic sequences of six botulinum neurotoxin-producing strains
RT representing three clostridial species illustrate the mobility and
RT diversity of botulinum neurotoxin genes.";
RL Infect. Genet. Evol. 30:102-113(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP006905; AIY84867.1; -; Genomic_DNA.
DR RefSeq; WP_039312513.1; NZ_CP006905.1.
DR AlphaFoldDB; A0A0A7FZ77; -.
DR STRING; 1561.NPD11_1787; -.
DR KEGG; cbv:U729_1214; -.
DR eggNOG; COG1757; Bacteria.
DR HOGENOM; CLU_018751_0_1_9; -.
DR OrthoDB; 9762978at2; -.
DR Proteomes; UP000030635; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR43478; NA+/H+ ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43478:SF1; NA_H_ANTIPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03553; Na_H_antiporter; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..197
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
FT DOMAIN 203..536
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 573 AA; 61769 MW; 5ED9F68E57DE26D9 CRC64;
MRKSRNYLVL GITIILMLCM TTVTFAAEVD QGALNAEKFG ILTIIPPLVA IILAFITKNV
VVSLFIGTLA GCFMLQIIDH NAFSSLIQAF LDFIQRVLNS LADPWNAGII LQVLAIGGVI
NLVSKMGGAR AIAEALARRA KTPRSAQMVT WFLGLLVFFD DYANSLIVGP IMKPVADKLR
ISRERLAFII DATAAPIAGL AIISTWIGLE VGLIKDSFTQ IGMDVDAFGV FLNTIPFRFY
NILILAFVVI TTLMLREFGP MRTAEIRARN GIKSKEVENN DSKLSEEMEA KEGVKLSVWN
AIIPIGTLII SALISFYYSG YSAIMAGDDS ALISILNNSP FSFEAIQQTF SAADASTALF
QSAIFASIVA ILMAVLKKIF TISEAIDVWI DGMKGLIITG VILLLAWSLS SVIKDLGTAK
YLVTLLSDSI PLFLLPSIIF ILGAVISFAT GTAYGTMGIL MPLAIPLSYS ISPDMGYIIV
STSAVLTGAI FGDHCSPISD TTILSSMGAG CDHIDHVKTQ MWYALFVGGF TILFGYIPAG
LNIPIYIILP IAIIALTIAV RFVGKPIDTV EEV
//
