ID A0A0A7HCC3_9CAUD Unreviewed; 193 AA.
AC A0A0A7HCC3;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN Name=frd {ECO:0000313|EMBL:AIZ02303.1};
GN ORFNames=VR20_245 {ECO:0000313|EMBL:AIZ02303.1};
OS Escherichia phage vB_EcoM_VR20.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Straboviridae; Tevenvirinae; Gaprivervirus; Gaprivervirus vr20.
OX NCBI_TaxID=1567027 {ECO:0000313|EMBL:AIZ02303.1, ECO:0000313|Proteomes:UP000030716};
RN [1] {ECO:0000313|EMBL:AIZ02303.1, ECO:0000313|Proteomes:UP000030716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kaliniene L., Meskys R., Simoliunas E., Zajanckauskaite A., Truncaite L.;
RT "VR bacteriophages - a small but diverse group of low-temperature
RT viruses.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|RuleBase:RU004474}.
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DR EMBL; KP007360; AIZ02303.1; -; Genomic_DNA.
DR RefSeq; YP_009207424.1; NC_028894.1.
DR GeneID; 26633923; -.
DR KEGG; vg:26633923; -.
DR OrthoDB; 9577at10239; -.
DR Proteomes; UP000030716; Genome.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 1..193
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 193 AA; 21607 MW; 4AF1776FA28EE8EF CRC64;
MIKLVFAYAP TKTVDGRDEN AFGLDDGLPW GHIKKDLQNF KARTKNSIVL MGAKTFESLP
STLKGRFHVV VADPARPYPV TKAGELAGGY IAWANYLKLI SGEKVSISAP DSPAQMFISS
ENYICVIGGK SLLEAAAPYA DEIVMTKIYK KHRVNSTVQL DNDFLYDISK REMLETHWYK
IDEVTHITET VYK
//
