ID A0A0A7KKY7_9DEIO Unreviewed; 294 AA.
AC A0A0A7KKY7;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:AIZ45238.1};
GN ORFNames=QR90_09225 {ECO:0000313|EMBL:AIZ45238.1};
OS Deinococcus radiopugnans.
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=57497 {ECO:0000313|EMBL:AIZ45238.1, ECO:0000313|Proteomes:UP000030634};
RN [1] {ECO:0000313|Proteomes:UP000030634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY59 {ECO:0000313|Proteomes:UP000030634};
RA Jung H.-Y., Kim M.K., Srinivasan S., Lim S.;
RT "Hymenobacter sp. DG25B genome submission.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP010028; AIZ45238.1; -; Genomic_DNA.
DR RefSeq; WP_039684041.1; NZ_CP010028.1.
DR AlphaFoldDB; A0A0A7KKY7; -.
DR STRING; 1182571.QR90_09225; -.
DR KEGG; dsw:QR90_09225; -.
DR HOGENOM; CLU_035117_1_1_0; -.
DR Proteomes; UP000030634; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000030634};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..294
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002029248"
FT DOMAIN 5..159
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..284
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 294 AA; 29702 MW; E1B2D7992B912BF6 CRC64;
MKTAAFLGLG AMGVPMAAAL ARRAAETGGR VLVWNRHADK AQAHAAEYGT QAAALEDVGQ
AGVIFSCLPT SADVDEVIGQ LEGHLNPGTV WVDCTSGHPD AAQSQRARLL TRGVRFLDAP
VSGGVSGAVA ATLTVMLGGP ADEVEAVRGE LAFAGKAVHV GDTGAGFAVK AVNNALLAVN
LWAAGEGLAA LGRGGVDLGA ALTVINASSG RSNATENLIP ARVLTRDFPP TFGLGLLAKD
IAIALDVVGG VRGSAPVLAQ VAALTRAAAQ MIGPDEDHTA LLKLVEQMNA QEIK
//
