ID A0A0A7S961_FRIPE Unreviewed; 367 AA.
AC A0A0A7S961;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Beta sliding clamp {ECO:0000256|ARBA:ARBA00021035, ECO:0000256|PIRNR:PIRNR000804};
GN ORFNames=FPB0191_02056 {ECO:0000313|EMBL:AJA45866.1};
OS Frischella perrara.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Orbales; Orbaceae;
OC Frischella.
OX NCBI_TaxID=1267021 {ECO:0000313|EMBL:AJA45866.1, ECO:0000313|Proteomes:UP000030901};
RN [1] {ECO:0000313|EMBL:AJA45866.1, ECO:0000313|Proteomes:UP000030901}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEB0191 {ECO:0000313|EMBL:AJA45866.1,
RC ECO:0000313|Proteomes:UP000030901};
RX PubMed=25527542;
RA Engel P., Vizcaino M.I., Crawford J.M.;
RT "Gut symbionts from distinct hosts exhibit genotoxic activity via divergent
RT colibactin biosynthetic pathways.";
RL Appl. Environ. Microbiol. 0:0-0(2014).
CC -!- FUNCTION: Confers DNA tethering and processivity to DNA polymerases and
CC other proteins. Acts as a clamp, forming a ring around DNA (a reaction
CC catalyzed by the clamp-loading complex) which diffuses in an ATP-
CC independent manner freely and bidirectionally along dsDNA. Initially
CC characterized for its ability to contact the catalytic subunit of DNA
CC polymerase III (Pol III), a complex, multichain enzyme responsible for
CC most of the replicative synthesis in bacteria; Pol III exhibits 3'-5'
CC exonuclease proofreading activity. The beta chain is required for
CC initiation of replication as well as for processivity of DNA
CC replication. {ECO:0000256|PIRNR:PIRNR000804}.
CC -!- SUBUNIT: Forms a ring-shaped head-to-tail homodimer around DNA.
CC {ECO:0000256|PIRNR:PIRNR000804}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR000804}.
CC -!- SIMILARITY: Belongs to the beta sliding clamp family.
CC {ECO:0000256|ARBA:ARBA00010752, ECO:0000256|PIRNR:PIRNR000804}.
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DR EMBL; CP009056; AJA45866.1; -; Genomic_DNA.
DR RefSeq; WP_039105852.1; NZ_QGTI01000005.1.
DR AlphaFoldDB; A0A0A7S961; -.
DR STRING; 1267021.FPB0191_02056; -.
DR GeneID; 78460423; -.
DR KEGG; fpp:FPB0191_02056; -.
DR HOGENOM; CLU_038149_4_2_6; -.
DR OrthoDB; 8421503at2; -.
DR Proteomes; UP000030901; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00140; beta_clamp; 1.
DR Gene3D; 3.70.10.10; -; 1.
DR Gene3D; 3.10.150.10; DNA Polymerase III, subunit A, domain 2; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR001001; DNA_polIII_beta.
DR InterPro; IPR022635; DNA_polIII_beta_C.
DR InterPro; IPR022637; DNA_polIII_beta_cen.
DR InterPro; IPR022634; DNA_polIII_beta_N.
DR NCBIfam; TIGR00663; dnan; 1.
DR PANTHER; PTHR30478:SF0; BETA SLIDING CLAMP; 1.
DR PANTHER; PTHR30478; DNA POLYMERASE III SUBUNIT BETA; 1.
DR Pfam; PF00712; DNA_pol3_beta; 1.
DR Pfam; PF02767; DNA_pol3_beta_2; 1.
DR Pfam; PF02768; DNA_pol3_beta_3; 1.
DR PIRSF; PIRSF000804; DNA_pol_III_b; 1.
DR SMART; SM00480; POL3Bc; 1.
DR SUPFAM; SSF55979; DNA clamp; 3.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000804};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR000804};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|PIRNR:PIRNR000804};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|PIRNR:PIRNR000804};
KW Reference proteome {ECO:0000313|Proteomes:UP000030901};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000804}.
FT DOMAIN 1..119
FT /note="DNA polymerase III beta sliding clamp N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00712"
FT DOMAIN 130..244
FT /note="DNA polymerase III beta sliding clamp central"
FT /evidence="ECO:0000259|Pfam:PF02767"
FT DOMAIN 246..366
FT /note="DNA polymerase III beta sliding clamp C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02768"
SQ SEQUENCE 367 AA; 41184 MW; 40F4F6569AABA2BE CRC64;
MKFIIDREKL IKPLQLVSAP LSSRPTLPIL GNLLLQVDDN VLSMTGTDLE IEMITRLPLY
EISESGATTV PARKFLDICR SLPANSQIAI KLEDNRLTIQ SGRSKFALST LPASDFPNLE
NWQCDVDFCI PQKTLKQLID SVQFSMASQD VRYYLNGMLF ETENNLLKTV ATDGHRLAVC
ALPIGQTIPT SCSVIMPRKG VLELAKLVSD NDELINIQIG SNNLRVNLSD ITFTSKLIDG
RFPDYRKVLP RNPDKILEAP CEVLRSALSR AAILSNEKFR GIRLYIHDNR IKITANNPDQ
EEAEEIIDVK YNAEPLEIGF NVTYLLDVLN VLKCETVRML LTDSTSSVQI ENINNQSATY
VVMPMRL
//
