ID A0A0A8E853_9COXI Unreviewed; 142 AA.
AC A0A0A8E853;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Iron-sulfur cluster insertion protein ErpA {ECO:0000256|HAMAP-Rule:MF_01380};
GN Name=erpA {ECO:0000256|HAMAP-Rule:MF_01380};
GN ORFNames=Z664_00145 {ECO:0000313|EMBL:AJC50173.1};
OS Coxiella endosymbiont of Amblyomma americanum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Coxiella.
OX NCBI_TaxID=325775 {ECO:0000313|EMBL:AJC50173.1, ECO:0000313|Proteomes:UP000059222};
RN [1] {ECO:0000313|EMBL:AJC50173.1, ECO:0000313|Proteomes:UP000059222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C904 {ECO:0000313|EMBL:AJC50173.1};
RA Raghavan R., Smith T.A.;
RT "Endosymbiont of Amblyomma americanum.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for insertion of 4Fe-4S clusters for at least IspG.
CC {ECO:0000256|HAMAP-Rule:MF_01380}.
CC -!- COFACTOR:
CC Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01380};
CC Note=Binds 1 iron-sulfur cluster per subunit. {ECO:0000256|HAMAP-
CC Rule:MF_01380};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01380}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family. {ECO:0000256|HAMAP-
CC Rule:MF_01380}.
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DR EMBL; CP007541; AJC50173.1; -; Genomic_DNA.
DR RefSeq; WP_039669748.1; NZ_CP007541.1.
DR AlphaFoldDB; A0A0A8E853; -.
DR STRING; 325775.Z664_00145; -.
DR KEGG; cea:Z664_00145; -.
DR HOGENOM; CLU_069054_5_3_6; -.
DR Proteomes; UP000059222; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProt.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.300.12; HesB-like domain; 1.
DR HAMAP; MF_01380; Fe_S_insert_ErpA; 1.
DR InterPro; IPR000361; FeS_biogenesis.
DR InterPro; IPR016092; FeS_cluster_insertion.
DR InterPro; IPR017870; FeS_cluster_insertion_CS.
DR InterPro; IPR023063; FeS_cluster_insertion_RrpA.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR NCBIfam; TIGR00049; iron-sulfur cluster assembly accessory protein; 1.
DR PANTHER; PTHR43011; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43011:SF1; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; HesB-like domain; 1.
DR PROSITE; PS01152; HESB; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|HAMAP-Rule:MF_01380};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|HAMAP-
KW Rule:MF_01380};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_01380}; Reference proteome {ECO:0000313|Proteomes:UP000059222}.
FT DOMAIN 15..137
FT /note="FeS cluster biogenesis"
FT /evidence="ECO:0000259|Pfam:PF01521"
FT BINDING 48
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01380"
FT BINDING 134
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01380"
FT BINDING 136
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01380"
SQ SEQUENCE 142 AA; 15869 MW; 0CEA4ECDF7558946 CRC64;
MNSNTSQVLS EKSSLSFTDA AVRKIKELIN EESKSGLNFR VFIKGGGCSG FQYNFAFDET
VNPDDFIIEK TVRKFAEKEN EKNKDTGYCH QMELVRLLVD PVSLQYLIGA EIDYREDVNG
SQFVIRNPNA KTTCGCGSSF SA
//
