ID A0A0A8EBL8_9ACTN Unreviewed; 892 AA.
AC A0A0A8EBL8;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=GZL_00906 {ECO:0000313|EMBL:AJC53510.1};
OS Streptomyces sp. 769.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1262452 {ECO:0000313|EMBL:AJC53510.1, ECO:0000313|Proteomes:UP000031113};
RN [1] {ECO:0000313|EMBL:AJC53510.1, ECO:0000313|Proteomes:UP000031113}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=769 {ECO:0000313|EMBL:AJC53510.1,
RC ECO:0000313|Proteomes:UP000031113};
RA Du Q., Wang Q., Li Q., Wang L., Zhang Z., Ren J., Wang J., Wang M.;
RT "Complete Genome Sequence of Streptomyces gongzhulingensis.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP003987; AJC53510.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A8EBL8; -.
DR KEGG; stre:GZL_00906; -.
DR HOGENOM; CLU_000445_113_1_11; -.
DR Proteomes; UP000031113; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AJC53510.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 367..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 621..838
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 838..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..857
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 892 AA; 93959 MW; 820DDA03462029E2 CRC64;
MAYAECHGRP ATEAMLDGLA VLPRAVRSHR GTEFGELDLD LVLERRPEVV LIDELAHTNA
PGCRHTKRWQ DVEELLGAGI DVVATLNIQH LESLTDVVEK ITGVPQYETV PDEVVRRADQ
IELVDLPAEG LRRRMAHGNI YPPEKIDAAL SRYFRLGNLS ALRELALLWV AGRVDEALRK
YRHEHRIGPV WETRERVVVA LSGGLEGTTL IRRAARIVNL SRALSSSPTL NCVRAGGPPC
AGGTPIPAGD LLAVHITRSD GLAGSSPAAL ADQRQLTESL GGTYHAVVGD DVPAALLDFA
RAQNATQLVV GASRRGRLRR FLAPRGVGET VVELSGDIDV HTVGHEYAGQ GRTWVIPGSG
LPHTRRVAGP IAGLVLPLLL TLVLRGVSGP LSLNLTSEAL LFLLTVLGVA CIGGVVSALL
ASVTTSLLLN YYFIPPVGQF TFAEANIVVA QAAFTTVAVT VAAIVDRSLR LGRRAARATA
EAETLSSLAG GILRGDRAVP DLLERTRETF GMDRIELCPR DDVPEPWPST TGRTAMGSAR
AVHTAGTAGD VGTDHRTEVA IGDDSVLVLI GRRLPASEHR VLTAFAAHLT AAVERARLAE
AAAEVESVKA ANRMRTALLA AVGHDLRTPL AGSWAAISSL RSREVDFSPE DREELLATAE
ESLAKLSRLV DNLLDMSRLQ AGALTLHLEP VALADVLPAA LDTLPGSPPQ APGRVVARAL
DTAPDVLADP PLLERVVANL VSNAVRHSPA GRPVTIGASA LGGRVEVRII DRGPGIQLPD
RERAFEPFQR LGDTDNTTGL GLGLALSRGL TEAMGGTLTP EETPGGGLTM VVSLPAAPEP
HLPESEEVPP PPATGVAVPP TAVRAEKVAA APHAVIARTV GAAGTAGTAD EA
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