ID A0A0A8EVL4_9ACTN Unreviewed; 6319 AA.
AC A0A0A8EVL4;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:AJC59844.1};
GN ORFNames=GZL_07292 {ECO:0000313|EMBL:AJC59844.1};
OS Streptomyces sp. 769.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1262452 {ECO:0000313|EMBL:AJC59844.1, ECO:0000313|Proteomes:UP000031113};
RN [1] {ECO:0000313|EMBL:AJC59844.1, ECO:0000313|Proteomes:UP000031113}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=769 {ECO:0000313|EMBL:AJC59844.1,
RC ECO:0000313|Proteomes:UP000031113};
RA Du Q., Wang Q., Li Q., Wang L., Zhang Z., Ren J., Wang J., Wang M.;
RT "Complete Genome Sequence of Streptomyces gongzhulingensis.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP003987; AJC59844.1; -; Genomic_DNA.
DR KEGG; stre:GZL_07292; -.
DR HOGENOM; CLU_223136_0_0_11; -.
DR Proteomes; UP000031113; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd02440; AdoMet_MTases; 2.
DR CDD; cd19540; LCL_NRPS-like; 5.
DR Gene3D; 3.30.300.30; -; 7.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF08242; Methyltransf_12; 2.
DR Pfam; PF00550; PP-binding; 5.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 5.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 702..738
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1355..1430
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2393..2468
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3432..3507
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4906..4981
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5969..6044
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 5599..5618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5949..5973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6319 AA; 681582 MW; 4FA8706C4E88BF32 CRC64;
MPGPFSVSRK KEELVIPLSF AQRRLWFLHK LEGASATYNM PLALRLKGEV DTEALRAALL
DVLERHESLR TVFPEVEGEP HQLVLDSEDV QLSWVHRTVT EDALPKVLEE AARHAFDLAS
EVPVRAWLLE TGTNDLVLMV LMHHIAGDGW SMGPLARDIA EAYTARVERR APGWSELPVQ
YVDYTLWQRE LLGDESDPDS VLNRQVSYWK DRLADLPEQV TFPADRPRPA VASYEGAQLT
FALDEELHRR LVELARNANG TVFMVLQAAM AALLTRLGAG SDIPLGSGIA GRTDEALDDL
IGFFVNMFVL RTDTSGDPAF KDLLGRVREA SLAAYEHQDL PFEHLVELLN PERSPAHHPL
FQVALVLQNA PSGAFELPGI QVQAEVLSSG TSRFDMLVSL TERHHPADGP QGIEVLVEYA
TDLFDRSTVE GLLARWTRLL EQVVEDPTRT IGELDLLAEA ERSTMLTAWN DTATEVPEAS
MAGLFERQVR RAPESTAVVR GTETLSYREL NARANRLAHW LIEQGVGPEH KVGVMLPRSV
DLVVAVLAVL KAGGAYVPVD LEYPAERRAF ILADAAPVLS LDEKALHTDV SGYPDTDPDV
ALSMDHPSYV IYTSGSTGIP KGVVVSHRGV ASLAHTQVQM LGINPASRVL QFASPSFDTA
FWDMLVAFSS GAALVVPERG RLVGQELQTV LAEGRVTHAL IPPSVVATLP PGASEELTDL
ECLVVGAEAV PPELVVRWSP GRRVMNAYGP TESTVIVTMA GPLDEGDVPI GRPVANSQVY
VLDEGLRPVP VGVAGELYVS GAGLARGYVK RAALTSERFV ASPLEPGARM YRTGDLVRWR
RDGQLEYMGR VDQQVKVRGF RIEPGEIESL LVAYEGVRQA AVVAREDTPG DQRLVAYVVP
DLEAAAASPA PASDTPASDT GADAQVEEWR EIYDSVYAGS GAGGFGEDFS GWDSSYTGDP
IPLDEMRAWR DAIVDQVRAT GARRILEIGV GSGLLMAHLA PDAEEYWGTD LSGAVIGRLS
RQVSEAGLAD RVRLRCQTAD TTEGLPPAYF DTVLINSVVQ YFPDGGYLAQ VIDQAMGLLA
PGGRLIIGDV RNAGSLRVLH AAVDAGRGAA ARAVVDRAVL LEKELVAAPE FFIGIAQRDD
RVGAIDIRLK RGGYHNELTR HRYEVILHKS PDSTVDLSDA RQLPWTPGLD LAELFADLDS
PVRVTGIPNA RLIGEVAAER ALDGHDAEEY GTGTDPEDLV AWGQERGQRV VTTWSSRSVA
LFDAVILPAQ MNDAVLTGVY LPATAGGPWV NNPAAVRAIG EVVEAARERL AEGLPDYMVP
SAVMVLDRLP LTPNGKLDRR ALPVPDYAAT AGGRGPRNPR EEVLCGLFAE VLGVERVGID
DSFFDLGGHS LLATRLVSRV RSVLGVELPI KDVFVAPTVA GLVARLGVGE GRSRAALVPA
VRPDIVPLSF AQRRLWFLHK LEGPSATYNV PLVLRLHGAV DAEALHTALR DVIARHESLR
TVFPEVDGEP RQLVLDPADV RFGWEHRSLP EEALPQALEE AARHGFELAA EIPVRAWLFE
SGPEESVLLL LVHHIAGDGW SMGPLARDVV TAYTVRTEGG APQWSALPVQ YADYTLWQRE
LLGEESDPHS IYAQQVGYWR EQLAGLPEQV TFPTDRPRPA VASYEGAHLT FALDAKLHRR
LIRLARRSNA TVFMVLQAAM AALLTRLGAG TDIPLGSPIA GRRDDALDDL VGFFVNTLVL
RTDTSGDPGF EELLGRVREA SLAAYEHQDV PFEHLVELLN PQRSTSHHPL FQVILGLQNA
AEPSFALPGL QVELEGVDLQ VSRADSVVNV TERRDRVGNP AGIDVLVEYA TALFDRSTVE
GLLARWVRLL EQVVADPSLP LSRVELLGGS ERRELVEVWS GTGVEVPEAT LAGLFEARVR
CVPEATAVAV GDRSVSYGEL NVRANRLAHW LVGEGVGPEK LVAVVLPRSV DLVVAVLAVL
KAGGAYVPVD PEYPVERRAL MLADADPVLV LDEAALGRDL SGFSDADPVV DVELGHPAYV
IYTSGSTGMP KGVVVSHRGV GSLVLSQVER FGVTSSSRVL QFASPSFDAA FSELAMALTS
GAVLVLPEAG GLAGDALVDA LTAHRVTHVT VPPSVLGALP LGVESVLSGL ETVVLAGEAA
SPELVARWAV GRRVVNAYGP TESTVCVSMS EGLSGAGDGV VPMGRPLANT RVFVLDEALR
PVPAGVAGEL YVSGAGLARG YVRRAGLTAE RFVASPFESG VRMYRTGDVV RWRADGQLEY
VGRADEQVKV RGFRIEPGEV EALLVASAGV RQAAVVVRED SPGDQRVVAY VVPDGEGLVD
TAVLLAQLGE RLPAFMVPSV VVSLDGLPLT PNGKLDRRAL PVPDYAATAG GRGPRTPQEE
VLCGLFAEVL GVERVGIDDS FFDLGGHSLL ATRLVSRVRS VLGVELPIKE VFGAPTVAGL
VARLDAAGGR SRTALVPVAR PEVVPLSFAQ RRLWFLHKLE GPSATYNMPL VLRLKGAVDA
EAMRDALLDV IGRHESLRTV FPEVDGQPGQ LVLDPADVRL GWERRTVSKA DLSTALDEAA
RHGFDLSSEI PVRAWLFEVG AEESVLLLLM HHIGSDGWSM GPLARDVVTA YTARAERQVP
EWSPLPVQYA DYTLWQRELL GDASDENSLF ESQVGYWRKQ LDGLPEQVTF PADRPRPAVA
SYQGALLSFE LDAELHRRMV GLARRSNATV FMVLQAAMAA LLTRLGAGTD IALGSPIAGR
RDDALDDLVG FFINTLVLRT DTSGDPAFEE LLGRVREASL AAYEHQDVPF EHLVELLNPQ
RSTSHHPLFQ VILGLQNAPE AAFALPGLQV ELEGLDLNVA KADLELNVIE RRDADGEPAG
VISAVQYATA LFDRGTVEGL LARWVRLLEQ VVADPSLPIG RVELLGEAER RELVTAWNDT
AVEVPELTLS ELFETQARRA PDAIALVSGD ESLSYGELNA RANRLAHWLV GEGVGPEKLV
AVVLPRSVEL IVALLAVLKA GGAYVPVDPD YPAERRAFML ADADPVLVLD EAALGRDLSG
FPDEDPEVEV AMEHPAYVIY TSGSTGTPKG VMVEHRAVAN YLNWTAHHYP AARGATLVPT
SIAFDLTVTG LYTTLTVGGR VYLDALDDLA HRENAVPVAF LKATPSHLPL LGDLPKQWSP
GEMLILGGEA LSGEVLAQWR REHRRVTVVN AYGPTETTVN CTEYRVGPKE KLPEGPVPIG
KPFWNTRAYV LDERLRPVPT GVVGELYVAG VQLARGYLGR PGLTAERFLA CPFEPGVRMY
RTGDLARRRP DGNLEYAGRA DEQLKIRGFR IDPGEIAATL QDHPDVRQAA VAARETDQGD
TQLVGYAVPN KDTGTAGIDT AALRAYLEER LPEYMVPAAV VALDAIPLTP NGKLDRRALP
APDFGALSTG RAPRTPQEEL LCGLFAGVLG VDRVGIDDSF FALGGHSLLA TRLVSRIRAA
LGVEIPISEV FASPTVAGLA TRLDAGGRAR TALAPMARPD AVPLSFAQRR LWFLHQLEGP
SAAYNWPFAM RLSGELDREA LQEALQDLVA RHESLRTVFR ATDGEPRQVV LEPAEAQLSL
IVEELAPERL HRAVQEAAGH RFGLDAEPPV RAWLFVPVAG HGPAGDEERD PVLVLLMHHI
VADGASRAPL MRDLAAAYEA RLAGSVPGGP PLPVQYVDYA IWQQELLGRA DDPDSLVSQQ
LTYWKEALDG IPSLLELPTD RPRPAIAGYH GDFLPLTLDA ELHAGLRKVA ADTRATLFMV
LQAGFAALLT RLGAGPDIPV GVPIAGRTDE ALADLVGFFV NTLVLRTDTA GNPPFETLLG
RARDTALGAY AHQDLPFEYL VEALNPVRSQ ASNALFQVMF ALQNTETATL RMQDIEVTPY
PLDSESAKFD LFLSLTEVLD DDGAPAGLSA TLEYATELFD RATVLRIAAW YERFLRAVVR
DPAARIGDIE LLSADERATA LQSRNGTATE PPSEWPHQKI ARQAARTPDA LAVRAGHEEV
TYGQLNRRAN QLARLLLDHG IGHECVVALA LPRSTDLVVA LLAVQKAGAT YLPLDPAHPA
DRLAYLVGDA APAALITTAA VRATLPEPLP ELSIQLGDPE AERRLTALAD TDVTDADRRT
PVHPAHAAYV IYTSGSTGYP KGVVVSHANL AHFLDAVTAR VPLTPDDHMV AATTITFDIA
AVEIYAPLLG GASVEIATDR VGKDPVALRR LITECGATVF QATPSMYRSL LAQDLGGLAG
VRLLVGGEAL PAALAEQLHA QGGGAVNLYG PTEATVWITA ADVTGPERPP LIGLPLNNAR
VYVLDDRLRP VPDGVAGELY LAGPFLARGY LDRRALTAER FVATPYGTPG ERMYRTGDLV
KWRADGGLEF LGRADDQAKV RGFRIELGEI EAALSRQPGI AAATVMVRED GGTPQLVGYV
VPDQDRSEGR DRAEDRRQVA SWQEVYDAVY RDQAAGGGFW EDFGIWKSSY DGTPIPLTEM
HEWRSAAVDA ILRLAPRHVL ELGVGNGLIL SQVAPHVDAY WGTDLSARAI ESLRARTAGD
PELAGRTELR AQPADDTTGL PEGYFDTIVL NSVAQYFPHA DYLTDVIRKS LDLLAPGGAL
FLGDIRNLRL LRHLQAGVTA RRLGPDADPD AARALLEQKV TDEEELLLAP DYFVRLGETL
DDIGGVDIRL KRAGHANELS RYRYDVVLHK SPAGAAPLAD LPELTWDAAG ATADGLTAAL
RAHPDGLRLA DVPNARLLAD HTALRAIEGG GDTGAPIPPT PGLDPEAVHD LAAAHGMDAV
TTWAESGRDD RFDAVLRPAG GTTPVAAYRG SATTRAAAPY ANSPARSRRL LDLNRELRSG
LRSWLPEYMV PAAFVVLDRL PLSPIGKLDR KALPAPDYGA LSVGREPRTP QEAELCGLFA
EVLGLERVGI DDSFFDLGGH SLLATRLVSR IRAVFGVEVP IGTVFDDPTV AGLAQRLDGS
GQARAALVPM ARPEAVPLSY AQRRLWFLHQ LEGPSATYNM PLALRLTGRI DQQALHAALR
DVVARHESLR TVFPEVGGEP RQLVLDPDRA DIGWEVRTLD ESELPAALEA AARHGFDLAT
EPPVRAWLFR TGPDRHVLLV LMHHIASDGW SLAPLAKDLV TAYTARQDGA APQWRELPVQ
YADFTLWQRE VLGSEDNPDS ALAQQVAFWR RMLAGAPEEL ALPTSRPRPD QPSHRGETVG
FELPAEVHRG LVELAARTGT SVFMTLQATM AVLLSRLGAG DDIVMGAPIA GRTDEALDDL
IGFFVNTLVL RTDLSGNPGF TELLARVRRT DLAVYAHQDL SFERLVELIN PDRSSSRHPL
FQVMMSLGNT GRPELTLPGL DVGFADAGTG AAKFDLDFLF SESFTDDGAP AGLGGVLRYA
TDLFDPDAAQ AIVTRLGMVA EAVTADSERP VGEIEILTDA ERHTALEEWN ATDHPVPDTT
LVGLFEQCAA AHPHAIAVES GGTRLTYAQL NACANQLARH LVRAGAGPEQ FIGLAVPTSV
ETLVALLAVL KSGAAYLPLD LKHPADRLAL ALDDTGPRQL LTTTEAQTLL PDTDHPRLLL
DSPETTELLA ALPSHDLTDA DRTTPLRPGN PAYVIRTSGS TGRPKGVVVE HRSVVNYLTW
TTEHYPAARG ATVVHSTLAF DLTVTTLYTT LLSGGRVHLT ALEDLPAGEQ PAEDAPLTFL
KATPSHLPLL AALPDRWSPA ELLILGGEAL TGAAVAPWRA VHPDVTLVNA YGPTELTVNC
AEFEIPPGAE LPSGPVPIGR PFWNMRAYVL DAGLRPVPPG VVGELYVSGA QVARGYLGRP
GLTAERFVPS PFEPGVRMYR TGDLARRRPD GQLEFAGRAD EQVKVRGFRI EPGEVAAVLT
AHPSVRQAVV VAREDGATGV QLVGYAVPAD PTAGLDAREL RAHIAAQLPD YMVPSAVVAL
DEVPLTPNGK LDRKALPAPD FTGAGPGRAP RTPREEVLSG LFAEVLGLDR VGIDDSFFDL
GGHSLLATRL MSRIRSVLGV DLPLRALFGT PTVAGLADRF DTGGEENALE VLLPLRTAGR
HRQLFCIHPG SGLGWTYAGL LQYIDQDIPV HALQARGLTG SEELPDTVEE MAEDYLEHIL
RVQPEGPYYL LGWSFGGVVA HTLAGLLEKS GRQVAQLTLL DCHPVNPVSR REVEEAMTKV
RVADVYRAML DLFDVELDDE ETENLTHENA MSMLRAKNSA LAGLTETEAK ALMEVTLNNS
LLGIDATPQP VAAPTLILAA TGGEHDHTLE PGVWDRYLTG PVEFRRTACR HTHMMNPEPL
REIGPIIAEK LRKNLTDGS
//
