ID A0A0A8F2N8_9ACTN Unreviewed; 695 AA.
AC A0A0A8F2N8;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Integral membrane protein {ECO:0000313|EMBL:AJC60691.1};
GN ORFNames=GZL_08145 {ECO:0000313|EMBL:AJC60691.1};
OS Streptomyces sp. 769.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1262452 {ECO:0000313|EMBL:AJC60691.1, ECO:0000313|Proteomes:UP000031113};
RN [1] {ECO:0000313|EMBL:AJC60691.1, ECO:0000313|Proteomes:UP000031113}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=769 {ECO:0000313|EMBL:AJC60691.1,
RC ECO:0000313|Proteomes:UP000031113};
RA Du Q., Wang Q., Li Q., Wang L., Zhang Z., Ren J., Wang J., Wang M.;
RT "Complete Genome Sequence of Streptomyces gongzhulingensis.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003987; AJC60691.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A8F2N8; -.
DR KEGG; stre:GZL_08145; -.
DR HOGENOM; CLU_005108_5_1_11; -.
DR Proteomes; UP000031113; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 160..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 188..308
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 695 AA; 72508 MW; 8B39AACBA0D552F5 CRC64;
MLFVCCGAFG WGVTDRLSSG GYEDSAAEST RAERVLAERF GAGSAQLLLV ARAPAPVTDP
SIVAAGRHLG AELNRVPGVT YAQSVWNTSD IRLKSSDGRA ALIRVRLDGD NRQVARHYDA
IVDQFTGRHG VFTISATGTV VAQREVAVDV RHDLVRSEAL AVPLVAVVLV WVFGSLVAAA
VPLVVGAFGL AATTAVLAAL TRVTEVSFFA LNITTALGFA LAVDYSLILV SRFRQELAAG
HAVPAALEVT VATAGRTVAY SAATVLLSVS GLALFPMGFF RSLCWAALSV VVFAAGAALT
VVPALLSLLG HGIDRGRLRT SGRSAVRGGR SAGECWAALA RWVIGRPGPV LLAATSVLLV
LAAPALGVRF GGTPYDWWTA PQAQWRMSTE QIQAQFPLAG GATPRVVLPD TPPPQARAYT
AELSRLPGVL AVGGPGGVYR AGHLQRSYGE IGRADARGTW VAVVTPFASS TEQARHLVQQ
LRAHPAPGPV LVGGDTAALI DGEDAVGGML GPVALVIVCA TGAVLWAFTG SVVLPLKALV
MNSLSFVAAF GVAVWVFQNG HLAGLVGASA RDSLDMRLPA LLACIAFGIG MDYELWLVSR
VAETYWQTGE TRASVVAGLR DAGPLISASA LILLIVTGAL ATAQVPGIKL MGFTFAAALV
IDLMLVRGLV MPAFMAVAGR WNWWPRRLDR YGGAP
//
