ID A0A0A8L308_9SACH Unreviewed; 490 AA.
AC A0A0A8L308;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 13-SEP-2023, entry version 21.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN ORFNames=KLDO_g1735 {ECO:0000313|EMBL:CDO93438.1};
OS Kluyveromyces dobzhanskii CBS 2104.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=1427455 {ECO:0000313|EMBL:CDO93438.1, ECO:0000313|Proteomes:UP000031516};
RN [1] {ECO:0000313|EMBL:CDO93438.1, ECO:0000313|Proteomes:UP000031516}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS2104 {ECO:0000313|Proteomes:UP000031516};
RA Nystedt B., Astrom S.;
RT "The genome of Kluyveromyces dobzhanskii.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDO93438.1}.
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DR EMBL; CCBQ010000025; CDO93438.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A8L308; -.
DR OrthoDB; 1341425at2759; -.
DR Proteomes; UP000031516; Unassembled WGS sequence.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
FT DOMAIN 37..368
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 434..486
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 490 AA; 52908 MW; 2E388579BAE2CE59 CRC64;
MLRSSFVSRG LRTNKGLAAG YQSLRMVSHR VETDAFGEIE VPSDKYWGAQ TQRSLQNFKI
GGPREKMPEP IVRAFGVLKK SAAVVNEGLG TLDPEVAKPI KQAADEVAQG KLLDHFPLVV
FQTGSGTQSN MNANEVISNR AIELIGGELG SKKIHPNNHC NQAQSSNDTF PSVMHIAAVT
EITRHLLPEL VALKDALKSK SDEFQDIVKI GRTHLQDATP LTLGQEFSGY VQQVENGIVR
VEQSMHHLKF LAQGGTAVGT GLNTKVGFAE KIAEQVSKET GIEFKTAPNK FEALAAHDAV
VEASGALNTL AVSLFKIAND IRYLGSGPRC GYGELSLPEN EPGSSIMPGK VNPTQNEALT
QVCVQVMGNH AAITFAGASG QFELNVFKPV MISNLLSSIR LLGDASNSFR IHCVEGIQAN
KDRIAKLLHE SLMLVTALNP KIGYDAASKV AKNAHKKGIT LKESALQLNV LSSEEFDEWV
IPENMIGPKD
//
