ID A0A0A8LBQ3_9SACH Unreviewed; 2231 AA.
AC A0A0A8LBQ3;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=WGS project CCBQ000000000 data, contig 00015 {ECO:0000313|EMBL:CDO95610.1};
GN ORFNames=KLDO_g3844 {ECO:0000313|EMBL:CDO95610.1};
OS Kluyveromyces dobzhanskii CBS 2104.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=1427455 {ECO:0000313|EMBL:CDO95610.1, ECO:0000313|Proteomes:UP000031516};
RN [1] {ECO:0000313|EMBL:CDO95610.1, ECO:0000313|Proteomes:UP000031516}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS2104 {ECO:0000313|Proteomes:UP000031516};
RA Nystedt B., Astrom S.;
RT "The genome of Kluyveromyces dobzhanskii.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] =
CC ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate;
CC Xref=Rhea:RHEA:13501, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145,
CC ChEBI:CHEBI:456216; EC=6.3.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000861};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-
CC CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001455};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDO95610.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CCBQ010000045; CDO95610.1; -; Genomic_DNA.
DR OrthoDB; 911at2759; -.
DR UniPathway; UPA00655; UER00711.
DR Proteomes; UP000031516; Unassembled WGS sequence.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF3; ACETYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}.
FT DOMAIN 59..568
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 217..409
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 695..769
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1484..1820
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 1824..2139
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 2231 AA; 249229 MW; 9B63503C47FED905 CRC64;
MSEENLSEVS VSQSKQYEIT EYGHKHSKLA SHFIGLNVVE KAEDSPLKEF VKSHGGHTVI
SKVLIANNGI AAVKEIRSVR KWAYETFGDE RTVQFVAMAT PEDLEANAEY IRMADQYIEV
PGGTNNNNYA NVDLILEVAE RADVDAVWAG WGHASENPLL PEKLAASKRR IIFIGPPGNA
MRSLGDKISS TIVAQHAKVP CIPWSGTGVD KVHVDKETNL VSVEDKVYQE GCCSSPEEGL
KKAKEIGFPI MVKASEGGGG KGIRKVENEE EFKTLYQQAA NEIPGSPIFI MKLAGKARHL
EVQLLADQYG TNISLFGRDC SVQRRHQKII EEAPATIAKP ETFTEMEKAA VRLGQLVGYV
SAGTVEYLYS HDDDKFYFLE LNPRLQVEHP TTEMVTGVNL PSAQLQIAMG IPMHRIRDIR
LLYGVDPKAA SDIDFEFSAP ESVKTQRKPI PKGHCTACRI TSEDPNEGFK PSGGALHELN
FRSSSNVWGY FSVGNNGGIH SFSDSQFGHI FAFGENRQAS RKHMVVALKE LSIRGDFRTT
VEYLIKLLET EDFEDNTITT GWLDDLISQK MTAEKPDRTL SVICGAATKA HIASEKARED
YISSLKRGQV PNKSLLQTMY PTEFIHDGMR YRFTVAKSAD DRYTLFINGS KCDVGVRKLS
DGGLLIAVGG KSHTIYWKEE VSATRLSIDS KTTLLEVEND PTQLRTPSPG KLVKFLVESG
EHVIAGQPYA EVEVMKMQMP LISQENGVAQ LLKQPGSTLI AGDILAILTL DDPSKVKHAK
PYEGMLPELG APNVEGTKPA YKFRSLVTTL ENILKGYDNQ VIMNASLQQL IEVLRQPELP
YSEWKLQVSA LHSRLPAKLN EQQEQLVSRS FKRGADFPAK QLEKMLEAAA NDPGVDALFG
TTIEPLVDIT TRYCEGLAAH EHFVFATFLE NYYNVEKLFS GPNIREEDVI LKLRDENADN
LEKVVLTVLA HSRVSARNNL ILAILKHYQP LCKLSSEVTA SIEQPLKHIV ELESKVTAKV
ALQAREILIQ GALPSIKERT DQVQYILKSS VLSTSYGSSE TKRTKPDLEV LKDLIDSNYV
VFDVLAQFLT NSDNAVSAAA AEVYIRRAYR AYTIGDLKHE KSSGSPVVEW KFQLPSAAFT
SLPQVKSKLG MNRAISVSDL TYVSEGESQP LRTGLLIPSR HLDDVDGILA SALSLIPSHH
VSTGPVPDRS GSSASLSNVA NVIVSSTEGF ESELDVLKRL REILDLNKEA LVESAIRRIT
FVFGYSDGTY PKYYTYRGPN YKEDETIRHI EPALAFQLEL GKMSNFNIKQ IFTENRNIHV
YEAVGKNSPV DKRFFTRGII RTGRIRDDIS ITEYLTSEAN RLMSDILDNL EIIDTSNSDL
NHIFINFSAV FDISPEAVEA AFGGFLERFG RRLLRLRVAA AEIRIIIKDP QTGTPVPIRA
LINNVSGFVV KTELYTEIKN AQGEWIFKSL DKPGSMHLRP IATPYPAKEW LQPKRYKAHL
MGTTYVYDFP ELFRQAIVTQ WKKYSPKNKL SDDFFIANEL IEDENGELTE VDRELGANNI
GMVAFKVTAK TPEYPHGRQF VIVANDITYK IGSFGPQEDA FFNKVTDYAR KRGIPRIYLS
ANSGARIGIA EELVPLFQIA WNDEQDPSKG FQYLWLTDAA LAELKSMGKE NAVVTDRVVE
EGKARNVITA IIGSEDGLGV ECLKGSGLIA GATSRAYKDI FTITLVTCRS VGIGAYLVRL
GQRAIQIEAQ PIILTGAPAI NKLLGSEVYS SNLQLGGTQI MYNNGVSHLT APDDLAGVEK
IMNWLSYIPA KRDLPVPILE SDDKWDRVVD FAPSLNEQYD VRWMIEGRKT PDGFEYGLFD
KDSFQETLSG WAKGVVTGRA RLGGIPLGVI AVETRIVENL IPADPANPDS TEVLIQEAGQ
VWYPNSAFKT AQAINDFNYG EQLPLMIMAN WRGFSGGQRD MYNEVLKYGS FIVDALVDYK
QPIITYIPPT GELRGGSWVV VDPTINADQM EMYADINSRA GVLEPEGMVG IKYRREKLLA
TMARLDDKYR ALKLKLADTN LPAEEHQEIS KQLATRERQL LPIYHQITVQ FADLHDRSGR
MLAKGVIRKE LDWPEARRFF FWRLRRRLNE EYLMRRLNTE LASASRLEKM SRIRSWYPAS
VSQDNDREVA TWIEENYQFL DEQVKSLKLE AFAQNLAKSI RNDRENSING LAEVLKLLST
SDKEKLQKAL E
//