ID A0A0A8UZI9_LEGHA Unreviewed; 703 AA.
AC A0A0A8UZI9;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=diguanylate cyclase {ECO:0000256|ARBA:ARBA00012528};
DE EC=2.7.7.65 {ECO:0000256|ARBA:ARBA00012528};
GN ORFNames=LHA_3175 {ECO:0000313|EMBL:CEK12159.1};
OS Legionella hackeliae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=449 {ECO:0000313|EMBL:CEK12159.1, ECO:0000313|Proteomes:UP000032803};
RN [1] {ECO:0000313|Proteomes:UP000032803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC35250 {ECO:0000313|Proteomes:UP000032803};
RA Gomez-Valero L.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN681225; CEK12159.1; -; Genomic_DNA.
DR RefSeq; WP_045107227.1; NZ_UGOC01000002.1.
DR AlphaFoldDB; A0A0A8UZI9; -.
DR STRING; 449.LHA_3175; -.
DR KEGG; lha:LHA_3175; -.
DR PATRIC; fig|449.7.peg.1703; -.
DR HOGENOM; CLU_000445_11_24_6; -.
DR OrthoDB; 9803824at2; -.
DR Proteomes; UP000032803; Chromosome I.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0052621; F:diguanylate cyclase activity; IEA:UniProtKB-EC.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR007891; CHASE3.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF05227; CHASE3; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08448; PAS_4; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotidyltransferase {ECO:0000313|EMBL:CEK12159.1};
KW Transferase {ECO:0000313|EMBL:CEK12159.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 13..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 300..354
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 563..697
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 703 AA; 80189 MW; 137C51736F9736BE CRC64;
MLKTIRPIKL NKVVLNFLFI TALLILSVVS YLSYSQLKNL IEANRLVNHT YEVIGKINVS
LYYLAEIESD QRAYLVSGDK NFLREINSSK ATLIDTLQIA SVLTKDNAKQ NEKVRRYKAL
IKERLELLAQ VTQLKANNQL NTPEGLSLFN RGSEISSAAK GLGQEIISVE EILLSERNNH
TLQNTKLGNI LLIVGSILSI IFLIVPFTLA NIELINRKII EHKNRTTRIH LRQIIESTND
MIAALDAKNR FEIFNEAYQQ EFKRLFGKSL LVGMNLEEAL SGIPQDRQHL LEIWQKSLQP
DESTKLLEFK HENGKTIYEL SATQIKNEQN ENKGLVHNVR DITSRVQEHS QLQDSYKKLA
EGMKELQLKN EQITLLVDMS DIMLAANSQE ELSKVMAKYA QALLAFSSGY LYIMHPSKNY
LEKASSWGQP HTQDQLITPD QCWGIRLGRI HQIKKADKEL VCEHIQITSK HPPTFICVPL
MAKNDIYGLL YIEIAEAKFI LNEETRLIIA AFTELTALAL ANVRLRENLR YQSIRDSLTG
LYNRRYLEDA LFKQIHQAER SKFSFALMML DIDHFKKIND NYGHDAGDVS LREVGKVLED
CTRQGDIAAR YGGEEFLIML HNIDLANAKK RAEQIRTTIS KLQIKYGAQP VIPLTVSIGI
AVFPKDSRNK DELTELADKA LYFAKAHGRN RVIAFSEIEQ SND
//
