ID   A0A0B0MTA5_GOSAR        Unreviewed;      1287 AA.
AC   A0A0B0MTA5;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Niemann-Pick C1 {ECO:0000313|EMBL:KHG02724.1};
GN   ORFNames=F383_26067 {ECO:0000313|EMBL:KHG02724.1};
OS   Gossypium arboreum (Tree cotton) (Gossypium nanking).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX   NCBI_TaxID=29729 {ECO:0000313|EMBL:KHG02724.1, ECO:0000313|Proteomes:UP000032142};
RN   [1] {ECO:0000313|Proteomes:UP000032142}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=cv. AKA8401 {ECO:0000313|Proteomes:UP000032142};
RA   Mudge J., Ramaraj T., Lindquist I.E., Bharti A.K., Sundararajan A.,
RA   Cameron C.T., Woodward J.E., May G.D., Brubaker C., Broadhvest J.,
RA   Wilkins T.A.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHG02724.1}.
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DR   EMBL; JRRC01289951; KHG02724.1; -; Genomic_DNA.
DR   RefSeq; XP_017642001.1; XM_017786512.1.
DR   SMR; A0A0B0MTA5; -.
DR   GeneID; 108483230; -.
DR   KEGG; gab:108483230; -.
DR   OMA; WWFDVES; -.
DR   OrthoDB; 2786103at2759; -.
DR   Proteomes; UP000032142; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR   GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004765; NPC1-like.
DR   InterPro; IPR032190; NPC1_N.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   NCBIfam; TIGR00917; 2A060601; 1.
DR   PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR   PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR   Pfam; PF16414; NPC1_N; 1.
DR   Pfam; PF02460; Patched; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032142};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ   SEQUENCE   1287 AA;  141531 MW;  1128CAE33851BC71 CRC64;
     MDFSRRKTGF LLSIALFQVL VIVQVAVAQT SNDERRQRHS EGYCAMYDIC GERSDRKVVN
     CPYGSPAVKP DELLSSKIQS LCPTITGNVC CTEAQFDTLR SQVQQAIPLL VGCPACLRNF
     LNLFCELTCS PNQSLFINVT SISKIKNNST VDGIDFFITD DFGEGLYESC KDVKFGTMNT
     RALEFIGAGA KNFKEWFAFI GRRAPNNMPG SPYAIQFLPT VPESSGMKPM NVSTYSCRDV
     SLGCSCGDCP SSPACSNTAI STSNKGATCS VQIGSLKAKC VDLALAILYI VLVSMFFGWG
     VFHRTRKRSR SFRMKPFTDA AEGGESHSLS RQKADNLPMQ RLEDANQSST GVQLSVVQGY
     MSDFYRKYGL WVARHPTLVL SLSVGMVLVL CLGLVRFKVE TRPEKLWVGP GSKAAEEKRF
     FDSNLAPFYR IEQLILATIP DALNGKSPSI VTEENIKLLF EIQKKIDGIR ANYSGSMISL
     TDICMKPMGE DCATQSVIQY FKMDPSYDAD DRLEHVNYCF QHYTSAESCM SAFKAPVDPS
     TVLGGFSGSN YTEASAFIVT YPVNNALDKE GNETQKAVAW EKAFVQLAKD ELLPMVRSRN
     LTFSFSSESS IEEELKREST ADAITILISY LVMFAYISLT LGDTPRLSSF YISSKVLLGL
     SGVLLVMLSV LGSVGFFSAI GVKSTLIIME VIPFLVLAVG VDNMCILVHS VKRQPLDFPL
     EGRISNALVE VGPSITLASL SEVFVFAVGS FIPMPACRVF SMFAALAVLL DFLLQVTAFV
     SLIVFDFLRA EGRRVDCFPC IKASSTYAES EKGIGGRKPG PLARYMKEVH APILNLWGVK
     IIVVAVFVAF ALASIALSTR IEPGLEQKIV LPQDSYLQGY FNNVSEYLRI GPPLYFVVKN
     YNYSSESIDT NKLCSISQCN SDSLLNEIAR ASLTPESSYI AKPAASWLDD FLVWLSPEAF
     GCCRKFTNGS YCPPDDQPPC CSPNDTACGL SEVCKDCTTC FRHSDLHNDR PSTAQFRDKL
     PWFLDALPSA DCSKGGHGAY TSSVELTGYE SGIIKASSFR TYHTPLNKQI DYVNSMRAAR
     KFASRVSDSL KMEIFPYSVF YMFFEQYLDI WKTALINLAI AIGAVFIVCL VITCSLWTSA
     IILLVLAMIL VDLMGVMAIL GIQLNAVSVV NLVMSVGIAV EFCVHITHAF SVSSGNRNER
     VKEALGTMGA SVFSGITLTK LVGVLVLCFS KTEVFVVYYF QMYLALVLLG FLHGLVFLPV
     VLSMVGPPSR CIRVEKQDER PSVSSQP
//