ID A0A0B1P3Y5_UNCNE Unreviewed; 439 AA.
AC A0A0B1P3Y5;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Putative transcriptional elongation factor iws1 {ECO:0000313|EMBL:KHJ31646.1};
GN ORFNames=EV44_g1085 {ECO:0000313|EMBL:KHJ31646.1};
OS Uncinula necator (Grape powdery mildew).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Erysiphe.
OX NCBI_TaxID=52586 {ECO:0000313|EMBL:KHJ31646.1, ECO:0000313|Proteomes:UP000030854};
RN [1] {ECO:0000313|EMBL:KHJ31646.1, ECO:0000313|Proteomes:UP000030854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=c {ECO:0000313|Proteomes:UP000030854};
RX PubMed=25487071;
RA Jones L., Riaz S., Morales-Cruz A., Amrine K.C., McGuire B., Gubler W.D.,
RA Walker M.A., Cantu D.;
RT "Adaptive genomic structural variation in the grape powdery mildew
RT pathogen, Erysiphe necator.";
RL BMC Genomics 15:1081-1081(2014).
CC -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC transcription regulation. May function in both SPT15/TBP post-
CC recruitment and recruitment steps of transcription.
CC {ECO:0000256|ARBA:ARBA00037349}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family.
CC {ECO:0000256|ARBA:ARBA00037992}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHJ31646.1}.
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DR EMBL; JNVN01002703; KHJ31646.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B1P3Y5; -.
DR STRING; 52586.A0A0B1P3Y5; -.
DR HOGENOM; CLU_045275_1_0_1; -.
DR OMA; RNNVQHA; -.
DR OrthoDB; 12240at2759; -.
DR Proteomes; UP000030854; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:KHJ31646.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Protein biosynthesis {ECO:0000313|EMBL:KHJ31646.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030854}.
FT DOMAIN 251..328
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 49965 MW; C7DF244189C41517 CRC64;
MSDSEPRVAS RNSEERYNDP EKNTSNIEPD KDLETSHSDN ESELSEVDEA EFAEFDPTTV
ALDDRPLVDI DEDVARSLKA SKRKRTDAIA RKPKDARRGR KKRLRRENDD DPDGIVLNGE
RIRKSKSGKY NRELQSGDRN KERRPLSPEN EENLTPDEKR RRALDKAMDA ALKQPSKRRR
KKDEVDLEEA FDDEIAALKL RMEQACEADN SARERSQPAI HKLKMLPEVI ALLNRNTVQH
SIVDPDTNFL QSVKFFLEPL NDGSLPAYNI QRDIFSALTK LPIEKEALLS SGIGKVILYY
TKSKKPEIEI KRTAERLLGE WSRPIMKRSD DYRKRQVVTK EFDHHAAQLA LRPSGLTGSQ
VSSSQGIRLA QREIERERIL AQPTGGNRAR IERSNSSYTV APKSTFDPSR GLDPSSRPIG
AGGIEAFRKM TAKQGRKRN
//
