ID A0A0B1P6S8_UNCNE Unreviewed; 461 AA.
AC A0A0B1P6S8;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Probable kinetochore protein NUF2 {ECO:0000256|ARBA:ARBA00017594};
GN ORFNames=EV44_g5724 {ECO:0000313|EMBL:KHJ34387.1};
OS Uncinula necator (Grape powdery mildew).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Erysiphe.
OX NCBI_TaxID=52586 {ECO:0000313|EMBL:KHJ34387.1, ECO:0000313|Proteomes:UP000030854};
RN [1] {ECO:0000313|EMBL:KHJ34387.1, ECO:0000313|Proteomes:UP000030854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=c {ECO:0000313|Proteomes:UP000030854};
RX PubMed=25487071;
RA Jones L., Riaz S., Morales-Cruz A., Amrine K.C., McGuire B., Gubler W.D.,
RA Walker M.A., Cantu D.;
RT "Adaptive genomic structural variation in the grape powdery mildew
RT pathogen, Erysiphe necator.";
RL BMC Genomics 15:1081-1081(2014).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|ARBA:ARBA00002772}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NUF2 family.
CC {ECO:0000256|ARBA:ARBA00005498}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHJ34387.1}.
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DR EMBL; JNVN01000896; KHJ34387.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B1P6S8; -.
DR STRING; 52586.A0A0B1P6S8; -.
DR HOGENOM; CLU_025461_2_1_1; -.
DR OMA; YLKMEAH; -.
DR OrthoDB; 7316at2759; -.
DR Proteomes; UP000030854; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.60; Ncd80 complex, Nuf2 subunit; 1.
DR InterPro; IPR005549; Kinetochore_Nuf2_N.
DR InterPro; IPR041112; Nuf2_DHR10-like.
DR InterPro; IPR038275; Nuf2_N_sf.
DR PANTHER; PTHR21650:SF2; KINETOCHORE PROTEIN NUF2; 1.
DR PANTHER; PTHR21650; MEMBRALIN/KINETOCHORE PROTEIN NUF2; 1.
DR Pfam; PF03800; Nuf2; 1.
DR Pfam; PF18595; Nuf2_DHR10-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030854}.
FT DOMAIN 27..167
FT /note="Kinetochore protein Nuf2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03800"
FT DOMAIN 279..395
FT /note="Nuf2 DHR10-like"
FT /evidence="ECO:0000259|Pfam:PF18595"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 159..256
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 320..438
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 54043 MW; 4F2B174C02CCEF5C CRC64;
MSYNHRMSMV ASSQQQIRGK KKEEESDAFM RLPDKEIVGC ISDIGVPFTV ADLQMPNPLQ
IQMIFEWFAE ILLNATRETV EPAMREAVED VCGEYIDIIP PETRNLMGFY VSLRKLLIEC
GITDFSFQDL YKPTHDRLVK VFSYIINFVR FRESQTAVID EHFNKAEVTK SRIENLIAEN
QEMELQLDEL KHNRRSVEAH LAEKVKRNEN IKRRLLDLRQ GQERVSRRFE NAKQKKNELT
KALEEKTTEI ILLRQESSRL KPYVLQSPAA LQGSLTELSN TLTSVKVEND VLDRRARSLQ
TSTDTFSIVS SDVSSCIKQL EDIIIEISKE DEENKRLTKQ RETLGDRRNS LKDIERTQNL
LQRQLSKWTE RTQKLRDGSE EKLLNAKIRM EELKQVHRNL TDERAEKGRE IEKKRIHIEQ
TEKKMSDLKE SIENEIHNAH DEFLKMDSHI KLYITELEQI I
//
