ID   A0A0B1PCH2_UNCNE        Unreviewed;       875 AA.
AC   A0A0B1PCH2;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN   ORFNames=EV44_g5679 {ECO:0000313|EMBL:KHJ35958.1};
OS   Uncinula necator (Grape powdery mildew).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Erysiphales; Erysiphaceae; Erysiphe.
OX   NCBI_TaxID=52586 {ECO:0000313|EMBL:KHJ35958.1, ECO:0000313|Proteomes:UP000030854};
RN   [1] {ECO:0000313|EMBL:KHJ35958.1, ECO:0000313|Proteomes:UP000030854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=c {ECO:0000313|Proteomes:UP000030854};
RX   PubMed=25487071;
RA   Jones L., Riaz S., Morales-Cruz A., Amrine K.C., McGuire B., Gubler W.D.,
RA   Walker M.A., Cantu D.;
RT   "Adaptive genomic structural variation in the grape powdery mildew
RT   pathogen, Erysiphe necator.";
RL   BMC Genomics 15:1081-1081(2014).
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHJ35958.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JNVN01000187; KHJ35958.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B1PCH2; -.
DR   STRING; 52586.A0A0B1PCH2; -.
DR   HOGENOM; CLU_007149_0_0_1; -.
DR   OMA; VTTWQAT; -.
DR   OrthoDB; 2786196at2759; -.
DR   Proteomes; UP000030854; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR044554; APC2-like.
DR   InterPro; IPR014786; APC2_C.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF08672; ANAPC2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM01013; APC2; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030854};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          536..752
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   875 AA;  100633 MW;  CBA8E845DDDC0743 CRC64;
     MPLNIVVQKQ NVFLSVFDVD KNRIPTEFNK SSSSGGKVNE KWLDLNSFQS QWHNSWLLVT
     KTLELPKNFE KYGSLEPKKK LIDSKFKNAL QILLRSKIES ISSDENVDIV AWLSSQVRQH
     YVNQVLPCIL QAKNLDTLEY DLFHSIGILE STRRLYEYKL LLIKQQMDIV SPGISITVIS
     KFQRDLDAII SNTIIDSISI PLARTLNRYV AIALKLTLPN DFSNNSIHVE NLDEEKAEEA
     LIKLVNRLKY IGLAGEGFQI IFAEVLNNAL SYFINGICHE TLSLKLTTAA KESSSERKSI
     ENFQLNHQRV SLNPSRCVKD IFEWIESRYA KLAFRVLGLL NNKINISWPE KLKFKDIGIS
     RLANFRCKQL FSIVTNWPHN GEALDDLRTA INTPERRLHL TELFAKTLAK EVLHPAASTT
     RILKTYISMI WSFHSLDQSK VLLDKVSYPL QLYLYTREDT VRIILSGLLA DTENSHSGNM
     GNKLLELAWL LNNESESISQ KANDIGLDWH DMDWIPDPVD AGPTYKRSKN ADIIGTLVSF
     LGSREVFIKE FQNILGDSFL KFDEMFSREI KVLELLKLHF GEASLQACEV MLKDIEISRE
     VDSKIQEIIQ SKIGISVGIQ DNQSFSKVDT DISKTFLHAK ILSRLFWPQL PNESFQIPPE
     IVELQTKYAK EFTLLKPSRK LKWLDTSGMA TIEIELEDRT LIENVHTWQA AVIWAFQNEG
     IDDQPQKRTI TELLNYLRME EGLIRSALRF WVNKYVLFET SLETYVVRET LSPQDQANLN
     SGSRPLSKHD EKIFDNKLDA INSVMNEKME IYWQFIQGML TNSSRQMPLQ QIAMMLKTLI
     IDGFPHTNDE LKEFLKQKIT DGLLELSSGK YRLKK
//