ID A0A0B1PCQ5_UNCNE Unreviewed; 2348 AA.
AC A0A0B1PCQ5;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Putative hsp90-like protein {ECO:0000313|EMBL:KHJ34711.1};
GN ORFNames=EV44_g5527 {ECO:0000313|EMBL:KHJ34711.1};
OS Uncinula necator (Grape powdery mildew).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Erysiphe.
OX NCBI_TaxID=52586 {ECO:0000313|EMBL:KHJ34711.1, ECO:0000313|Proteomes:UP000030854};
RN [1] {ECO:0000313|EMBL:KHJ34711.1, ECO:0000313|Proteomes:UP000030854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=c {ECO:0000313|Proteomes:UP000030854};
RX PubMed=25487071;
RA Jones L., Riaz S., Morales-Cruz A., Amrine K.C., McGuire B., Gubler W.D.,
RA Walker M.A., Cantu D.;
RT "Adaptive genomic structural variation in the grape powdery mildew
RT pathogen, Erysiphe necator.";
RL BMC Genomics 15:1081-1081(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHJ34711.1}.
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DR EMBL; JNVN01000741; KHJ34711.1; -; Genomic_DNA.
DR STRING; 52586.A0A0B1PCQ5; -.
DR HOGENOM; CLU_001037_0_0_1; -.
DR OMA; QLPGYTW; -.
DR OrthoDB; 1222064at2759; -.
DR Proteomes; UP000030854; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43047:SF46; HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000030854};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 85..360
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1934..2159
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 2201..2325
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 455..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1503..1533
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 2256
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 2348 AA; 263392 MW; F1312B056101D144 CRC64;
MVGEFLDYAP AGLYERLRQI DGYTWDESKP PYHSSYNNWV VFGTQDANKA QNYSNNCTTH
RENHSGQQVT SNDRECNSQI EPDHNHVKQV IARVSTHVLR EERAYHICMN MLKKSDPDAN
YFILPIKLVQ LPSQPGDVGP LIVSILEYEG PNYLLRVIDY GPAYYTGRRV GDDHEYPGDN
APLEPMELET FMDFAVGATE CLEILHHREH IAHGEIRGDA FHMNTESRKV KILNFGSGLR
TFEHGLTSNG WSMLSKEIGA KTKLCFMAPE QTGRMPTEPD SRTDIYSLGI LFWTILIQQP
AFCGETPMDI IQAVLGRRLP LVSNIRLDIP DVIGRIIQKM TSKMIGDRYH SASGLKYDLV
EVRRLLGIGD SLALKNWKIA TRDVSSFFIL PTIMIGRSKE RDKIVKVIDN VSRHYLASST
YEPHSASSVG LGLTEGRLEC SETSLGIVDQ LSSDGDAASS MDGRSSPFTS NSLSGDTRWN
KSSSNHLRSA TNSFQHSSHD SLDSSGRLIP IFKPWEKIST SSFDCSRNIV ESINSDQHSK
ILSDGVNSFI NLRNSNRRHR KGCCEIVTIA GAAGLGKTCL VQSIQIEARR RGYFASSKFD
QAKRTAFGPV LKLLSSLFKQ VFSESDTETP FHQILKRYVQ PAWPLLHKVL DLPVFLIGNT
DVSMPNRINH SGFISQQNYN KNLRSDLRKR DTSPSSKNTI CNMPLVTQSA QDFFRAGSST
KSLRLLNTCL DVLRVFVQHK FICLCLDDLQ FADDESLDFL SQILASGMKI VIIVTYRPEE
SLSDKVKCIV DPSFTKDNLN GFGVGITQIN LLPLGEEDTR KYVAETLRRD EPDIASLADI
IRSKTGGNPF NMREMLNSCY RRRCIYYDYK ENGWCHDIEK IFKEYSGSIS ESNLNCEFAM
SRLKELPLVS KAILVWASYV GNSFSFNLIR RLLGGEFDYD DDNPNLNLIK NTSLYTQQDI
IEGLQTVIQA CIITETQDDD RFCFTHDRYM QAASSLDLYP TPKVHFIIAQ TLLKYKLSED
CDKDTIAMHI GKSIDIIKAR VKHRRTFREV LFDCAQSATE NGAPNTAVRF YQKCFSLLQD
DPWEDQAVDV YYHETLELHI RAAECYVYTG HDSEATKLLE IIFSQAHTEV EKAPAWVLKS
RIYAQKGDSF SAFRALKACL AGLGIDVDDE PSFEKCDADF EKLIFKIKSM DIENLINRPE
SKDSDLSAVG IVLVETISAA YWTDRLRFYQ MTLVMVNIHL TYGEFPQVGM AYIHLATIAI
SRFNMIKFAC QMAEVSHTLV DRWQDPYTIG RRKTSYSNFV GHLEVKLQDS LPQLEESFDY
SIQAGDRIAT ILNFGLIGHM KFFLSENLVD LEAFICYGCE EVPNWSYDTR GGTLAIAARQ
TCRALQGKTS IAEPLDVMSD EQHDSQNYKL WLKKTVENSD LQIFFYETLE IAPTFLYGHY
DRAVEIGESC LKLTDTVWSA RHTRFLMLIY GLSLSSLIWL KISDPLRTVS SGLCGVRSEA
EYLESENALL KELEDSITQL KFLKRKIEDW QAVSDVNYLS WSKLLSAQIA EMEGHHSIAM
KKYEQSLDNA SANKHLFDEA LGNYLLAGFF LRSGSRRAAK EAMREATHLF RTLGAIGVAN
YIENQHILLL QDPMKIERTL DVAVQTSVAA ASDHVRFVSL QGVEESSLAR SQTMSAEVDI
CKSGVWPGDS EQEIAESGLL ALDMLDLTSI LKSSQVISSV LQIDQLLKTM CEIILHNCGG
LATTAAIVVD EDSVGWSIAA SGDPEKGAEA HIPGIPLGET AIVAEGVILY CARFRETVFV
PDLIRDERFS NVMEAWAARN PHGKSVIAIP ICHGNESLLG VLYLEGEPNA FTDRNLTLLQ
LLVNQIGISY SNALTWKEVE KVSASNKAMV ALQKAALKKS LIAEEKANQA KAEALRNVEL
AEEAVKAKSI FLANVSHELR TPLNGVIGNS ELLRDSCLTK DQAEMADSIR VSADLLLTVI
NDILDFSKIE ADKMELYIVA FRANEMMREI FRSVSFSNKG KRKNVSIMDD IKLPGCLVFG
DPVRLHQVLG NLVSNSMKFT EFGSIVVGAR TDVETKDDLR LKFWVRDTGI GIPQQKLDKL
FKPFSQADAS TARKYGGSGL GLSICKSLVE TMMGGKIGLE SIEGQGTTCW FTITFPKASN
KASPGDLPNN EQNNSRTVEL EPEVSKTPFY NLSHIPREEI RVCIAEDNPV NKKIAIQFMH
KLGFRSVDAY ENGLEAVEGL RLKAKEGKPY HIVLMDVQMP VLDGYEATKL IRQDPIDKIR
RILVIAMTAS AIQGDREKCL ASGMNDYLAK PVRSNVLKDK LDYYLRQSPS LTSNSSQKIS
IGIKKSQR
//
