ID A0A0B1PK06_9BILA Unreviewed; 187 AA.
AC A0A0B1PK06;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=tRNA-specific adenosine deaminase 2 {ECO:0000256|ARBA:ARBA00019216};
DE EC=3.5.4.33 {ECO:0000256|ARBA:ARBA00012740};
DE AltName: Full=Deaminase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00033441};
DE AltName: Full=tRNA-specific adenosine-34 deaminase subunit ADAT2 {ECO:0000256|ARBA:ARBA00031817};
GN ORFNames=D918_07777 {ECO:0000313|EMBL:KHJ42054.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KHJ42054.1, ECO:0000313|Proteomes:UP000053709};
RN [1] {ECO:0000313|EMBL:KHJ42054.1, ECO:0000313|Proteomes:UP000053709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mitreva M.;
RT "Draft genome of Trichuris suis.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probably participates in deamination of adenosine-34 to
CC inosine in many tRNAs. {ECO:0000256|ARBA:ARBA00002255}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA +
CC NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-
CC COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33;
CC Evidence={ECO:0000256|ARBA:ARBA00001103};
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DR EMBL; KN538407; KHJ42054.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B1PK06; -.
DR Proteomes; UP000053709; Unassembled WGS sequence.
DR GO; GO:0008251; F:tRNA-specific adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0002100; P:tRNA wobble adenosine to inosine editing; IEA:InterPro.
DR CDD; cd01285; nucleoside_deaminase; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR028883; tRNA_aden_deaminase.
DR PANTHER; PTHR11079; CYTOSINE DEAMINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11079:SF149; TRNA-SPECIFIC ADENOSINE DEAMINASE 2; 1.
DR Pfam; PF14437; MafB19-deam; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053709};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 3..120
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|PROSITE:PS51747"
SQ SEQUENCE 187 AA; 20959 MW; 9C4C7C2950FC8921 CRC64;
MPAVENEYLN QAFRLAEEAL ASGEVPVGCV LVRDQRVIGS GRNAANECRN GTRHAEMVAF
DQAIRWFDSQ EVPTTFDLTS AFLYVTSEPC MMCAAAICQL KVGTLVFGCR NERFGGFGSV
VHVQNVFGYQ YPVQVYPDVC RDRAIALLQR FYEGENPNAP VANVKRKRKI QVCAEDRKYK
KQTTDFG
//
