ID A0A0B1T0S2_OESDE Unreviewed; 421 AA.
AC A0A0B1T0S2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN ORFNames=OESDEN_09311 {ECO:0000313|EMBL:KHJ90834.1};
OS Oesophagostomum dentatum (Nodular worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Strongylidae; Oesophagostomum.
OX NCBI_TaxID=61180 {ECO:0000313|EMBL:KHJ90834.1, ECO:0000313|Proteomes:UP000053660};
RN [1] {ECO:0000313|EMBL:KHJ90834.1, ECO:0000313|Proteomes:UP000053660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OD-Hann {ECO:0000313|EMBL:KHJ90834.1,
RC ECO:0000313|Proteomes:UP000053660};
RA Mitreva M.;
RT "Draft genome of the hookworm Oesophagostomum dentatum.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000301,
CC ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167,
CC ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167, ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN552609; KHJ90834.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B1T0S2; -.
DR Proteomes; UP000053660; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF145; EG:EG0003.4 PROTEIN-RELATED; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718};
KW Reference proteome {ECO:0000313|Proteomes:UP000053660};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..421
FT /note="UDP-glucuronosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012362023"
SQ SEQUENCE 421 AA; 47653 MW; 914260DAADBF578B CRC64;
MRLLALLILL PGCCSLNILL FLLGTNQFER HTFEFLAQQL ALRHHNVITV KPILIPEEPR
LVKPKLHLVR EKTLKNMLPK KQYEDLEKAG DVIPWTTNYE EEAYDEVYWA AHNTSCYKMI
NSNLLDTLQK DALDVAIVYS GNPCQLALAH VLAVPVIYYD LEGLSDETVV ASNSPLNLDI
PPSKCFLPEI NFLHSLSRIR NGICYMKEYL VQSGIPPISR LISKRYRQLD DPISTMFAED
YNFKKRFKEF PLTTSLLRSS AFFFANTDPL LEFPRALSPR VIPVGGLHID VPKPLFAVKA
ILGALSRLTK YRIYWRIGHK VELKGVKEKD VPDHINLTAF IPQNDLLAHK SCRLLVTNGG
MSSLMEAVAH GVPVVGIPLY GSNRHNLRKV VNKGLGLVVN KDELTEQKLY TTMKTVLQGT
K
//
