GenomeNet

Database: UniProt
Entry: A0A0B1T2L6_OESDE
LinkDB: A0A0B1T2L6_OESDE
Original site: A0A0B1T2L6_OESDE 
ID   A0A0B1T2L6_OESDE        Unreviewed;       444 AA.
AC   A0A0B1T2L6;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   03-JUL-2019, entry version 16.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   ORFNames=OESDEN_08330 {ECO:0000313|EMBL:KHJ91793.1};
OS   Oesophagostomum dentatum (Nodular worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Strongyloidea; Chabertiidae; Oesophagostominae; Oesophagostomum.
OX   NCBI_TaxID=61180 {ECO:0000313|EMBL:KHJ91793.1};
RN   [1] {ECO:0000313|EMBL:KHJ91793.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OD-Hann {ECO:0000313|EMBL:KHJ91793.1};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Oesophagostomum dentatum.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; KN551809; KHJ91793.1; -; Genomic_DNA.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713}.
FT   ACT_SITE    103    103       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   DISULFID     14    304       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    180    193       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    329    340       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   444 AA;  50465 MW;  5DDECBDB0671B270 CRC64;
     MDGHVYWNVP SKVCYTRKVD IPLQEFGITY NKGHEFLGDQ IVIFYEYKFG YFPYYVDYDA
     NQPVNGGLPQ NCPLDKHLAL VSRQIREAIP REDFEGIAVI DFEEWRPLYQ LNWGKKSVSY
     KKESVRLVKE QFPTISDKSA EEIAKKEFNA AAKKLFLSTI ALARHLRPYA RWGFYGFPYC
     NYDAGNTESD MLCSEKFRRY NDEMSFIYEA SSALFPSIYL SLKGTSAQNY RYIQAVLVES
     ARIASLQNPV LDVYPYTKFE YNPYHFLDSF YAKKDVCNSL KQAADLGARG IVLWSSSKNM
     KQRCDGLGNY VRDMLGPTVA LIRKRSQRCR EKRCSGHGQC VLPEPASSSA ALFRCTFRMQ
     PSNYVSGDAG KETEDGSPAQ AEIVVVDVTP SSAQAEQDTL VPTKVKPIRP SSNKTIPEMP
     VPGELITLDP ILRITPEPLD FRLA
//
DBGET integrated database retrieval system