ID A0A0B1TBN1_OESDE Unreviewed; 2345 AA.
AC A0A0B1TBN1;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Integrase core domain protein {ECO:0000313|EMBL:KHJ92750.1};
GN ORFNames=OESDEN_07357 {ECO:0000313|EMBL:KHJ92750.1};
OS Oesophagostomum dentatum (Nodular worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Strongylidae; Oesophagostomum.
OX NCBI_TaxID=61180 {ECO:0000313|EMBL:KHJ92750.1, ECO:0000313|Proteomes:UP000053660};
RN [1] {ECO:0000313|EMBL:KHJ92750.1, ECO:0000313|Proteomes:UP000053660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OD-Hann {ECO:0000313|EMBL:KHJ92750.1,
RC ECO:0000313|Proteomes:UP000053660};
RA Mitreva M.;
RT "Draft genome of the hookworm Oesophagostomum dentatum.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN551154; KHJ92750.1; -; Genomic_DNA.
DR Proteomes; UP000053660; Unassembled WGS sequence.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 2.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF51283; dUTPase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053660};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 190..204
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 976..1147
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 237..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1344..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1191..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2345 AA; 262214 MW; C02868AFC2893CDC CRC64;
MPLPDGESLP VVFSGLTLGQ LAPKNIGTFS GLANQDFESW LRKFEDVVRM VNPPLPEQLK
TNTLVGFLEG EARDLVEEMQ DADKNSYDRL KPALRFHVKA ANPANFDEAV VKAITYESLL
ADVANSLSIL PGVQPAVPAV NVISSAQNPT RYEGRNDQQR DNFRNRQVRN YSNNFNRRVW
ERAPNSNVVC YRCGKSGHIQ TFCRFSLPPA NLRPPRQQFP VRNNFRSGRI NQNSQQQFGY
GRSVAQQPTV PQQRNDGRNP SRVLALEQTS ATEDPNPEEL SIIQQKDAHI AALIDRNNAL
ADIAFATRNP KPQNDGEESS SYQSTQINCT KILPNWSATA QPLKIKVFRP NTIRYKSVAN
VCRIITQTII YSVNFFGARS QKILSQEQTV STGVCRHMAT VYAYHGSSTI ESSIGPLEGC
QYKDGACTTK SGSAIIWEPE TQESCRYVLV SPMKGVLIDK FAHNDSVIKF YPVTGVYEII
PSSKVTVIQH STNRPQAIVK PALTLFHNLV ITNISEFVPG QQFTELWSAI EALIDTGSSI
TLAAQDLCAA LGIFQLDHPQ TSSAMGMAGI LVPMAGSKEV IMQIGNIELH PTIHFTKGPC
VPNMNSDYEV IIGHDILAQL PPMTIDYKAQ KVCFGAMVLH LGTLSNSNNS GEPPPYPVRV
KDTTVLQPNA ECFVSCTVPI APPKDLVLVS QCSKIANKDL IVAPALISSN SPVVLVSNPT
SQPVTLYAGM RLADASEVVQ EGETLAESGD TFSPPAISCV SELTSNDPTY KINLTNSDLT
ESERKQLVQL LDSFADVFSR HQYDIGSCTA GKVHIYTTND PPSRIRPYRV PMKYREELQK
HVNMLLKCGV MKESHTPWVH NLVVVRKKDN SLRVCLDMPS EMANKTIIRP NGCLYYHFER
NGTKDLLLLV PDSLRQLLFD AYHSSALSGG HMGWKKTLAK ILRKYYWPTI YGDIHRWCES
CLTCQMRRKP KPEFRERLIP VHSEAVFAKV GLDLCGPLRP TERGNKYILN IVCWFTRYVI
SMPLPDARAN TIAHALFTEC VLKYGTMSEL ISDQASSFTS HFYQEFCNLL HIQQKFATPY
HSMGNGATER TFSTFQMMLS KFINTKQEDW DLFIPCVTFC YNTTINEATD LMSQSDSAAL
SILNQGVAST EEPSEKQPDQ PVETDLEVSS GVVEVKMDEE TDEHAAEVAP TATSDSPTPQ
VPANTPETTT DQVQPVTFPK GPARQTSLNV CGSSSEGEEP QSDRSSRSGS KAHSGKGALE
KPTTSRGSVR RKITRSFYEQ TRSYSRSPSD SESDMEAEVP VKKAKPSDEV ETALASLVEQ
ATLIQSVPPQ KVPPSKAILY KPQDEEWKQK EKKSSHREME SFKTHPYRRD LRSKRAPVIS
PYYNTNLDAA EFEEMPTSGY AGIIEGIFPE PNEGVPKSLR SKITILDAVG PHAIEDFRAR
HSYDYMFDKN GRKTRLRTMA LADPATDEEK NTYMHGLEFD QGIAPVLYRV KTLFGTGAKL
EAVHFEVFLP DRYDLAIITI DQYAINVKTE KRGLDITKII VGDLVWVYSL AVTTKFATTE
HRKPTTIAAA YRLREATVWR VERFALIYRE LRPTLGFVTR IVSQQDGTFE LYMQGHRGLV
TVNRNRLEDP NSFELIKPNS FIVAPFRPRQ LNYVVFACSV RDQMSMLATL IDIQMPYIPG
PSPAPFNIRV NSVEHQQLVN SKLTRFDLFS TSPTEVLAFL EPLYSTSCGV IAASVRAATD
SAAHATAWRS PNINSFPILV TFTIPIQRKT GWAVGSTIRG SYESDFMDGQ IVNVKREKYE
SYLEVTAKLE TDSGVRFRSC ILNARYDNIL VRTFLYTIEE RANPVLTMLE KCVISDILHP
NSLGWMSARA LLAGDIQLEG IDNPDQESIT VSVDGTDVTL NQHQVNAVNQ FNKEYPILIV
DSAYGAGKSL CTAVMAMEAV RKDETILVAA VQNTALDVIG LKIAQLQNKD IRPIRYVNDT
IGADPDITSP FALQTLMETF HETHGHLLTK YWYAKFRKFS ESRREMREFY FTGTQRHVVT
REHRRLLLLE QDASEDVKVL VARFLKFYNP NVYLCTISAS LNLTSKKGLW RRLGNKWKRV
LVDEASMVPE SAIIAMLARF QNAKFTLVGD SKQLPPYVGV NHVPLAVEIS STSILDVAQK
HGRVPVCMVS TVYRPHEEMM KLNSELFYDG QLICGTPREM RMGLLSRLRM PNSSLPVALV
DVCGHSIQSV TGSHSNEVEA RAVLVLTTNV TVGTVDSAQG SERSVVILCT TRTHVERTSK
PTFFSDPRRL NVALSRAKDG MFILGLKSYL QKVETWSAIV EWCEQHGAAT TLDYFDALMR
PRFHY
//
