ID A0A0B1THP7_OESDE Unreviewed; 730 AA.
AC A0A0B1THP7;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=SWIRM domain protein {ECO:0000313|EMBL:KHJ97063.1};
GN ORFNames=OESDEN_02965 {ECO:0000313|EMBL:KHJ97063.1};
OS Oesophagostomum dentatum (Nodular worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Strongylidae; Oesophagostomum.
OX NCBI_TaxID=61180 {ECO:0000313|EMBL:KHJ97063.1, ECO:0000313|Proteomes:UP000053660};
RN [1] {ECO:0000313|EMBL:KHJ97063.1, ECO:0000313|Proteomes:UP000053660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OD-Hann {ECO:0000313|EMBL:KHJ97063.1,
RC ECO:0000313|Proteomes:UP000053660};
RA Mitreva M.;
RT "Draft genome of the hookworm Oesophagostomum dentatum.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR038051-1};
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|ARBA:ARBA00005995}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN549528; KHJ97063.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B1THP7; -.
DR Proteomes; UP000053660; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140682; F:FAD-dependent H3K4me/H3K4me3 demethylase activity; IEA:UniProt.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0010558; P:negative regulation of macromolecule biosynthetic process; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 1.10.287.80; ATP synthase, gamma subunit, helix hairpin domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR017366; Hist_Lys-spec_deMease.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007526; SWIRM.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR PANTHER; PTHR10742:SF386; LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR Pfam; PF04433; SWIRM; 1.
DR PIRSF; PIRSF038051; Histone_Lys-demethylase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50934; SWIRM; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR038051-1};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR038051-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053660}.
FT DOMAIN 44..142
FT /note="SWIRM"
FT /evidence="ECO:0000259|PROSITE:PS50934"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 181
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
FT BINDING 187
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
FT BINDING 205..206
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
FT BINDING 697
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR038051-1"
SQ SEQUENCE 730 AA; 83011 MW; 8467A997ED36E14F CRC64;
MTHTEERSHS RRDHSSELDS ESIKQLLEDG ELETLRWEDD DISLRSAASN SRLPYDKLTA
QELVHFPDAS DSKASTNLYL FVRNKILQLW LLEPNVELTS EDAIEQLPIP FNSDRRFVRR
IHGFLQRYGF INYGNFHRLA SALVLTSKRK RVIIIGAGAA GIAAMKQLHY FGFDVVVLEG
RKRLGGRVHT YHQKDSSVVA DLGAMVVTGI NGNPIVTMMR QTQCTPVRIS PECPIYDEYG
KLVDQRKDEL VAEAFKKIGD TAAYIAHTLG VTEVNGNKLS VADAYNNILD MLELRMQRRR
LKYWQIYEEI LEKMKQVQNE ITLYKKSAVY LAEKLKSSDG SIPLTLDSDS RLEMDILRRC
YKRDLGEAIK RYDATRERFR NLETTLRNLK KQEPSEVYMN QRDRRLLDFH FANLEYVSGG
TLDRLSLQHF DQEDEFQFTG SHMAIRDGYG DFLTRLVTSD VASMIKQNAV VESIKYNEKG
VEVQYKTDDS ICTIDGDVCL CTIPLGVLKR SVMEASDAPK FEPPLPENTI KAIIEMGFGN
FNKVVLIFSR PFWDVTQNYF GHLNHSRSSR GEMFMFTAVS KAPVLIAMMA GEAANLEAPN
EVIVRKAMNV LANIFGSACP KGVSLQFFFL LHNSQRLSQP VEAVITRWHK DPFACGAYAY
IPCGSRGDLC DILAEPIRAQ AADGTYSGEE RIFFAGEHTS GRYPASVQVQ LLWIISYYFC
IIEEKSISMR
//
