ID A0A0B1TWQ2_OESDE Unreviewed; 789 AA.
AC A0A0B1TWQ2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Histone deacetylase family protein {ECO:0000313|EMBL:KHJ99905.1};
GN ORFNames=OESDEN_00090 {ECO:0000313|EMBL:KHJ99905.1};
OS Oesophagostomum dentatum (Nodular worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Strongylidae; Oesophagostomum.
OX NCBI_TaxID=61180 {ECO:0000313|EMBL:KHJ99905.1, ECO:0000313|Proteomes:UP000053660};
RN [1] {ECO:0000313|EMBL:KHJ99905.1, ECO:0000313|Proteomes:UP000053660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OD-Hann {ECO:0000313|EMBL:KHJ99905.1,
RC ECO:0000313|Proteomes:UP000053660};
RA Mitreva M.;
RT "Draft genome of the hookworm Oesophagostomum dentatum.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:61930; EC=3.5.1.98;
CC Evidence={ECO:0000256|ARBA:ARBA00001028};
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DR EMBL; KN549201; KHJ99905.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B1TWQ2; -.
DR Proteomes; UP000053660; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF15; HISTONE DEACETYLASE; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053660}.
FT DOMAIN 406..719
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 65..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 85155 MW; 4FC4CC45CEA9B295 CRC64;
MDLMAHFERA QQALNMQHLQ QYYQTLQQHA QQQAASSAAQ SGPERMDEGL CDAAVAPLAL
ASSMGSLLGS SQSPTTSREA PPPQRIRSEH RNASTSSTSQ TISQHTKDRL KNMIAQRNRE
GSQTNLAGTP PQQHAPMSPQ VNVSSPHFEP YRVPASLHTA QAASSQPSSE YQLRKVNSEP
NLKMRIRAKL LSKGSSPVQN QNSFNFTHPQ LKRSDSETSG NGNTAGNLAM DALLTNAAAT
AFPPHLIMPS PSLPNLAAPT LAQAPQLPID LASLMAAAQL TPFLSLPSLF KTHIGLGAGL
LEEDVADRTK LTPGVATLGA LSQQLPVFGN PSLLKQQLRE LVLRRKSLVR EEPEDDDSLS
TQPVLSPGQM PSTLGLGDLS GGKATGLAYD SSMARHECVC GESSSHVEHG GRVQSIWARL
LERGLVQKCE RIAAKKASLE QLRLVHSPTY VTFFAVSPTA CLKMEPSQLP LKSFVQLPCG
GIGIDSDTYF NDATTQTAAR VAAGSLIELA SQVAENRLRN GFACIRPPGH HSERDQAMGF
CFFNNVAITA RYLQNKYPQQ CARIAIIDWD VHHGNGTQLC FEEDPSVLYL SLHRHDNGNF
FPGTGAVTEI GRGAGKGFSV NVPFSGDVMR DADYLAAWRV IVHPVLEQFQ PTFILVSAGF
DACSGHPNAL GGYKISAEMF GFMTRQLMNF AGGRVVLALE GGYDLASISD AAEQCVKVLC
GEDDKAGVLK NEALEGLPCL SAQETIQKVI AIHKGYWPTL TAEQGLSISE LHWQTVGRQF
QKLTMGTVS
//
