ID A0A0B1YJ10_9RALS Unreviewed; 369 AA.
AC A0A0B1YJ10;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=PI87_01870 {ECO:0000313|EMBL:KHK58525.1};
OS Ralstonia sp. A12.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Ralstonia.
OX NCBI_TaxID=1217052 {ECO:0000313|EMBL:KHK58525.1, ECO:0000313|Proteomes:UP000030970};
RN [1] {ECO:0000313|EMBL:KHK58525.1, ECO:0000313|Proteomes:UP000030970}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A12 {ECO:0000313|EMBL:KHK58525.1,
RC ECO:0000313|Proteomes:UP000030970};
RA Chen J.W., Yin W.F., Chan K.G.;
RT "Draft Genome of Ralstonia A12.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHK58525.1}.
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DR EMBL; JSZO01000001; KHK58525.1; -; Genomic_DNA.
DR RefSeq; WP_039595974.1; NZ_JSZO01000001.1.
DR AlphaFoldDB; A0A0B1YJ10; -.
DR STRING; 1217052.PI87_01870; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000030970; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KHK58525.1}.
FT DOMAIN 25..353
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 369 AA; 39600 MW; FE5E99349C38964D CRC64;
MQSTAPAAPQ TDVQPNVIAE VRGGIGWLTL NRPQALNALS LEMIRAMSHA LMAWQHDPAV
HAVILRGEGG KALCAGGDIR FFHRAATAGD PQLVTFFTEE YRLNHLIFQY AKPYIALMDG
VVMGGGMGIS QGASLRVVTE RTKMAMPETN IGLFPDVGGG WFLARVPGHV GEYLGVTGQM
IEAADALSIG LADCHVTTEA LATVVQRLRE GAWQSAEQIV ACFTEAATAP GAAKALIGPH
RTAIDACFGQ ATVPAILAAL ADSTDADWAA QTAAHMAKRS PMMMAVTLEL IRRGRHTTLA
DELRRELDMM THVFAEGDGV EGIRALAVDK DHSPKWKHAG IDAVRDDEVA AFFVSPWRRE
QHPLLGLSD
//
