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Database: UniProt
Entry: A0A0B1YK72_9RALS
LinkDB: A0A0B1YK72_9RALS
Original site: A0A0B1YK72_9RALS 
ID   A0A0B1YK72_9RALS        Unreviewed;       532 AA.
AC   A0A0B1YK72;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   13-FEB-2019, entry version 35.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=PI87_08645 {ECO:0000313|EMBL:KHK57283.1};
OS   Ralstonia sp. A12.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=1217052 {ECO:0000313|EMBL:KHK57283.1, ECO:0000313|Proteomes:UP000030970};
RN   [1] {ECO:0000313|EMBL:KHK57283.1, ECO:0000313|Proteomes:UP000030970}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A12 {ECO:0000313|EMBL:KHK57283.1,
RC   ECO:0000313|Proteomes:UP000030970};
RA   Chen J.W., Yin W.F., Chan K.G.;
RT   "Draft Genome of Ralstonia A12.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KHK57283.1}.
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DR   EMBL; JSZO01000004; KHK57283.1; -; Genomic_DNA.
DR   EnsemblBacteria; KHK57283; KHK57283; PI87_08645.
DR   Proteomes; UP000030970; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030970};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      229    363       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      440    509       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     237    244       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   532 AA;  59444 MW;  97A683607C480221 CRC64;
     MQDFWHAASA QLESELTPQQ FKTWIKPLTP LSFDEQACTL RIAAPNRFKL DWVKSQFSGR
     IQSLACDYWE MQVDVQFVLD PTAGQRAVQQ PAFAPAPMQS MVGQAVQPAQ AMPVAGSMAH
     NPAAVRPAPA MYRETALATA SHGVGHTAAD IDVPVMDAAE VSAQSYRMPP AAPAVVATLA
     APPQAPVDDT VHERSRLNQI LTFDNFVTGK ANQLARAAAI QVANNPGKSY NPLYLYGGVG
     LGKTHLIHAI GNFMLMENPR ARIRYIHAEQ YVSDVVKAYQ RKAFDDFKRY YHSLDLLLID
     DIQFFSGKNR TQEEFFYAFE ALIANRAQVI ITSDTYPKEI TGIDDRLISR FDSGLTVAIE
     PPELEMRVAI LMKKAQAENV TVPEEVAFFV AKHLRSNVRE LEGALRKILA YSNFHGKEIT
     IEVTREALKD LLTVQNRQIS VENIQKTCAD FYNIKVADMY SKKRPANIAR PRQIAMYLAK
     ELTQKSLPEI GELFGGRDHT TVLHAVRKIA DERTKDAQLN HELHVLEQTL KG
//
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