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Database: UniProt
Entry: A0A0B1ZEA6_9SPHN
LinkDB: A0A0B1ZEA6_9SPHN
Original site: A0A0B1ZEA6_9SPHN 
ID   A0A0B1ZEA6_9SPHN        Unreviewed;       265 AA.
AC   A0A0B1ZEA6;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE            EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN   ORFNames=LK12_19875 {ECO:0000313|EMBL:KHK89394.1};
OS   Novosphingobium malaysiense.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Novosphingobium.
OX   NCBI_TaxID=1348853 {ECO:0000313|EMBL:KHK89394.1, ECO:0000313|Proteomes:UP000031057};
RN   [1] {ECO:0000313|EMBL:KHK89394.1, ECO:0000313|Proteomes:UP000031057}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MUSC 273 {ECO:0000313|EMBL:KHK89394.1,
RC   ECO:0000313|Proteomes:UP000031057};
RA   Lee L.-H.;
RT   "Genome sequence of Novosphingobium malaysiense MUSC 273(T).";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC         Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC         Evidence={ECO:0000256|ARBA:ARBA00001156};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC       biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005010}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHK89394.1}.
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DR   EMBL; JTDI01000007; KHK89394.1; -; Genomic_DNA.
DR   RefSeq; WP_039288174.1; NZ_JTDI01000007.1.
DR   AlphaFoldDB; A0A0B1ZEA6; -.
DR   STRING; 1348853.LK12_19875; -.
DR   OrthoDB; 9815856at2; -.
DR   UniPathway; UPA00262; UER00222.
DR   Proteomes; UP000031057; Unassembled WGS sequence.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR   GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR028161; Met8.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006367; Sirohaem_synthase_N.
DR   NCBIfam; TIGR01470; cysG_Nterm; 1.
DR   PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   Pfam; PF13241; NAD_binding_7; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF75615; Siroheme synthase middle domains-like; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031057}.
SQ   SEQUENCE   265 AA;  27670 MW;  D3B4677758DD28A8 CRC64;
     MIETLPLFHR ISGQPVVVLG AGEAAEAKRR LVQRAGGLVI DDLQEGIDKG ARLAFIAHDS
     DSAAEADAIR ARCAGLLVNA TDRPALCDFT VPSILDRSPV LVAIGTGGAS AGLAKQLRLR
     LEQLLPQSLG PLATALGKAR AALRTRFPDA GARRRALDAA LGAGGALDVL TEVAPGRVEH
     WLGEKADPDP TGAVEIVLRS DDPEDLTLRE ARLMGSADIV AFEPGVPRKV LERARADASR
     VAVAPGQIPA GEGLVVLLRG PERRG
//
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