ID A0A0B2B2J7_9ACTN Unreviewed; 554 AA.
AC A0A0B2B2J7;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Protein ImuB {ECO:0000313|EMBL:PJJ54145.1};
GN ORFNames=CLV56_3649 {ECO:0000313|EMBL:PJJ54145.1};
OS Mumia flava.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Mumia.
OX NCBI_TaxID=1348852 {ECO:0000313|EMBL:PJJ54145.1, ECO:0000313|Proteomes:UP000230842};
RN [1] {ECO:0000313|EMBL:PJJ54145.1, ECO:0000313|Proteomes:UP000230842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27763 {ECO:0000313|EMBL:PJJ54145.1,
RC ECO:0000313|Proteomes:UP000230842};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): From Individual Species to Whole Genera.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJJ54145.1}.
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DR EMBL; PGEZ01000002; PJJ54145.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2B2J7; -.
DR OrthoDB; 5244088at2; -.
DR Proteomes; UP000230842; Unassembled WGS sequence.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd03468; PolY_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR Pfam; PF00817; IMS; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000230842}.
FT DOMAIN 31..99
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 379..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..421
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 58791 MW; 15EB8C6C31B12424 CRC64;
MARALVLWCP DWPVRAVTHT GLGLDLPAGA PVAVVEGGEV VACSARARTD GVRRGQRMRD
AQARCPELVV TERDPGHEAR AYEPVLALVE EVAPGVQPLR PGTCAIRVAG PARYFGGERH
AAAVLAERLV TYGVDDVRAG IADSVFTAEQ AARRALPQDS LVVPAGASGA FLADLPVAVL
ERPDLASLLQ RLGLRTLGAF AGLDAADVRD RFGSDGALAH RLARGVDDRP FASRRPPSDF
EREVAFEPPL VDSEAVAFSV RRAAEEMVSA LAAHQTVCTS VWIEVRTDRG EVTERQWLHP
RWFDAGDLVD RVRWQLSAGS ASAVSGPVEA VRFVPAECAS VTEHADGLWG SGPDERVHRA
ASKVQSMLGR EAVVSVVLGG GRGPADRQTA VPWGDPLEPA RSPSPPWPGS LPPPAPARVY
DPPRPAEVVG VDGRPVVVSE RGALSGAPAR FAVGGSRPGE GSRSLAGSRF DQRDGAAGSR
FDQRDGAAGS RLDQRSGDGL HPVQAWAGPW PVDERWWDAA SAVRAARFQV VGVDGTAWLL
RVGDDGWCAE AQYD
//
