ID A0A0B2UKH5_9MICR Unreviewed; 816 AA.
AC A0A0B2UKH5;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
GN ORFNames=M896_040300 {ECO:0000313|EMBL:KHN69838.1};
OS Ordospora colligata OC4.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Ordosporidae;
OC Ordospora.
OX NCBI_TaxID=1354746 {ECO:0000313|EMBL:KHN69838.1, ECO:0000313|Proteomes:UP000031056};
RN [1] {ECO:0000313|EMBL:KHN69838.1, ECO:0000313|Proteomes:UP000031056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OC4 {ECO:0000313|EMBL:KHN69838.1,
RC ECO:0000313|Proteomes:UP000031056};
RA Pombert J.-F., Haag K.L., Beidas S., Ebert D., Keeling P.J.;
RT "The Ordospora colligata genome; evolution of extreme reduction in
RT microsporidia and host-to-parasite horizontal gene transfer.";
RL MBio 0:0-0(2014).
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557,
CC ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC ECO:0000256|RuleBase:RU365061}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN69838.1}.
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DR EMBL; JOKQ01000004; KHN69838.1; -; Genomic_DNA.
DR RefSeq; XP_014563880.1; XM_014708394.1.
DR AlphaFoldDB; A0A0B2UKH5; -.
DR STRING; 1354746.A0A0B2UKH5; -.
DR GeneID; 26261469; -.
DR VEuPathDB; MicrosporidiaDB:M896_040300; -.
DR HOGENOM; CLU_018541_0_0_1; -.
DR InParanoid; A0A0B2UKH5; -.
DR OrthoDB; 55913at2759; -.
DR Proteomes; UP000031056; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.132.70; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR021891; Telomerase_RBD.
DR InterPro; IPR003545; Telomerase_RT.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF12009; Telomerase_RBD; 1.
DR PRINTS; PR01365; TELOMERASERT.
DR SMART; SM00975; Telomerase_RBD; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000031056};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061,
KW ECO:0000313|EMBL:KHN69838.1};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 368..683
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 816 AA; 94488 MW; D43A24EA837FE90A CRC64;
MLNLLKSLHF QTLRSFLSEY ITEHLPDVVD TIYVKSSCVP NITSFECTQS CVSLISKAVR
CLVDRGMSNQ LCSGYILSTD EADPGKILCT SPFVSSNMLK SHEWTCVINA IGDQLAVHLL
TECTLVQKAN NVYVLLAGDF SSLYKMYQKP VNMRINRDTI FHKHIRVVSF VAVKAFEYIF
QEHNLHKYKT MQTDVMHVLQ KIERSVAHLP LSPMFKSYFH CEINIENKTG IMECSIKYSK
LVDFLFLISK KLFANVFDFE SFRILKSRIS LLVHRNRYEN ISNTEMMKYF KISRFKFFRS
VKCTRHEFCV RSRIVNRFLT YITENIFVAV MSKYFYSTET SFSKFKVYYF PRSSWRYFSS
MHISSFLDRF ETIEPCKPYL YSELRCIPKA NGMRVVCNMS KARDGKQSIN SRVYPEFCIL
RNECYGNLGN SVINQAGMYE KLAPYLSSVR GEAYILKVDV SGCFDSIPQE HVMRIVKDTI
NKSTYYISNI SALEAAGIEV RCRQIYKASN NIMTANTLVE DACGVKLRNK LVKENAGQRV
LRKEEVCNAI AKVINKNVIR YHGKHFVQRT GIPQGSIAST LLCSLYYNKI DELYFNAILK
DGMLVRYVDD FLVISPSLDE ILRFLQVFQS ISHLGMNLSS QKIESNFGIE KYMKHSDWIT
DAIMHKSDLR IIDKPVIWCG MKIYANGFCV KPCVADPYMM FSITHAVHHP GQGVAMKIGN
MLRNRMSKMY IDRTNLKTYE NIYDIFLLCG KKLVLHLKRM DFINQKFVAN VLENSKMFII
KTCRERGVSI SKRMIESMSS KAFEKSGLYK IMQIRE
//
