ID A0A0B2ULY2_TOXCA Unreviewed; 1122 AA.
AC A0A0B2ULY2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=gcy-1 {ECO:0000313|EMBL:KHN72046.1};
GN ORFNames=Tcan_07780 {ECO:0000313|EMBL:KHN72046.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN72046.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN72046.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN72046.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN72046.1}.
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DR EMBL; JPKZ01004117; KHN72046.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2ULY2; -.
DR STRING; 6265.A0A0B2ULY2; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF375; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-13; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KHN72046.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 237..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 884..1122
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 1122 AA; 124387 MW; 9018AA0481B0DC19 CRC64;
MLLPRYSPQL IPLDGYTRSA SAAMLAVQRL GRENKLNDVN FTMGVAICAT MQQYNWTEFG
LIYASTTIGM GSCFYLQQDL EAALSYFSST LALVYVRIIP INISNFSEVL DDLRMHARIV
VTCFESDAQK VNFMLQAKAK SMSTPEYVYI FPDLGNTGFG VGNTRFWDNE TAIQGNSEIL
EAFQYALMSF SCLFWSSTTD ELNNTFIRAQ TMHTRLGRFP SDIRRTKEMT AYDKIRPVAL
TSAIYFLGVL FSVAGQLMPN LSEMGGPQVT QQQDVVRLLR SLLRPLRASV TAAVWNVTSM
TTTFTVAALY ISQKFIPVLE QFIQTSRCAG SSASSSKRFE QGGIDEAITR TLVLTQLNTQ
DVQSTPNFSA EVIDHMKDYP FYCTIECPTN VSVSCLVVAF FIKGSLLQGM GAEGVGDSNH
DIRRTKEMTA YDKIRPVALT SAIYFLGVLF SVAGQLMPNL SEMGGPQVTQ QQDVVRLLRS
LLRPLRASVT AAVWNVTSMT TTFTVAALYI SQKFIPVLEQ FIQTSRCAGS SASSSKRFEQ
GGIDEAITRT LVLTQLNTQD VQSTPNFSAE VIDHMKDYPF YCTIECPTNV SLRASVTAAV
WNVTSMTTTF TVAALYISQK FIPVLEQFIQ TSRCAGSSAS SSKRFEQGGI DEAITRTLVL
TQLNTQDVQS TPNFSAEVID HMKDYPFYCT IECPTNVSAA EYAATLFNAM YLYGIALNKS
LAQDPVNGWR SGRRILENAV GHFNGSTGIV VIGRNGTRNP VYSIDAVNIG AGGLSGYATI
EVEGINYSFT PLYTDAASSI WASRGGHAPP SLPICGFSGN HCPVNFFKRY WGYVAAVGVL
IATAFIALVA GSIYLVREKI RGAERENSMW QIPFTRLARP DDNNNCKSLR SLGSFRSSVK
SQTVSMTESD NIVHYSLDRD LVYAEKFHIR VQLTSENCAD LRRMRTLEHG NVNRFVGLVL
DAPMYLVVWK FCSRGSLQDV IQAGKIQIDG FFAYCLMRDI VDGLNALHSS AVGYHGMLTS
ANCLIDERWQ LKISNFGLHF LRRLKKPTDD DLLWTAPELL RDSTLGGSKS GDIYSFAIIC
SELMCLTPPW NLGERKEQSA EIIYMVQHGV VPPFRPERLS FS
//
