ID   A0A0B2UPT9_TOXCA        Unreviewed;       520 AA.
AC   A0A0B2UPT9;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Bifunctional coenzyme A synthase {ECO:0000313|EMBL:KHN73011.1};
GN   Name=COASY {ECO:0000313|EMBL:KHN73011.1};
GN   ORFNames=Tcan_11285 {ECO:0000313|EMBL:KHN73011.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN73011.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN73011.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN73011.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN73011.1}.
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DR   EMBL; JPKZ01003171; KHN73011.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2UPT9; -.
DR   STRING; 6265.A0A0B2UPT9; -.
DR   OMA; EIHCHEV; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:InterPro.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.
DR   CDD; cd02022; DPCK; 1.
DR   CDD; cd02164; PPAT_CoAS; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR   PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR   Pfam; PF01121; CoaE; 1.
DR   Pfam; PF01467; CTP_transf_like; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT   DOMAIN          153..294
FT                   /note="Cytidyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF01467"
SQ   SEQUENCE   520 AA;  57086 MW;  EFC05E1F18CA88A1 CRC64;
     MECSSDSASI RTTFTVDPFG LPIEGSLSLS YMRSDQSSSP RYYGNSNNSL ANDAMVDVGL
     LIVGSRCAKS LASALTSASK LVNGRLYVRI CSGVDIYEVL PKVYLEASRV CDSLDVRVLL
     DEGSTRKFDK VFSEGDDVAA PSHHISRPYH AVVLGGTFDR LHNGHKVLLS AAVLAASERI
     VCGVTFGEMT HKKCLWELME PFEVREKAVK EFVEDVSNKV RCEVHPITDP FGPAIVDPDL
     EAIIVSSETI KGGHAVNEER KKRGLSKLTV ESIRLVDGED KILGETKISS SARRRALLGT
     IRRPLKIAGN AFPRPFVIGL TGGIASGKSN AAKVLARNKC QVIDCDKLAH ELYKKGSTMA
     LKIGETFGAH ILNDGVVDRK ALGRIVFADK EKLKLLNDIV WPSLRAAVEQ IIVTSEAEFV
     VVDAAILLEA EWDREGVVHQ VWSCIVPPEE AMQRMFDRDG TAPEEVKATR KLAIQMSNAE
     RVERSDVVIC SLWAYEETAR QLESALHELK QISKSYSRSS
//