ID A0A0B2US63_TOXCA Unreviewed; 925 AA.
AC A0A0B2US63;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 6 {ECO:0000313|EMBL:KHN72089.1};
GN Name=Trpv6 {ECO:0000313|EMBL:KHN72089.1};
GN ORFNames=Tcan_15013 {ECO:0000313|EMBL:KHN72089.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN72089.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN72089.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN72089.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN72089.1}.
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DR EMBL; JPKZ01003647; KHN72089.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2US63; -.
DR STRING; 6265.A0A0B2US63; -.
DR OMA; FRELILM; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF2; INACTIVE; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KHN72089.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 173..205
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 223..255
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 393..649
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 764..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 105068 MW; B1910FE88F50A250 CRC64;
MGQLKSKILR SEDANLGNPK ADPDEKWSNL YREREKNHLY KWVGVRTGGE LISAFEKDGE
DGVLRFANDK LISMMYEDGE SPQLIRFADY AKWKKTVNVQ LGKAEDNAEI SPTESKFREH
LAQWKLNKRG VEGETIVHLL LTREEPMCSE IARILINRFP GLANDIYLGD EMFGQSTLHL
AIVHDDYETV QLLLQNGADV NARACGAFFI PEDISDYQGY AYYGEYPLAF AACFGNKDIY
DLLIQYGADP NLQDMYGNTI LHMCVINYSN SMYSYAVRHW EKPADPNIVN AAGLTPLTLA
TKLGRKDIFE EMLELMKVEF WRFSDMTCSA YPLTALDTIR PDGSTNYDSA LMTVINGSTA
EHLDMIGSEV IQRLLADKWK AFASRKLFER LGLLALHLVF LCFVVYLRPT EPERLTYQRN
RTSWDDWLRL FFEIMTIASC VFFVFFQQLG ELRTQGFYGY VRNLKTAPAK IVFLGANICI
LACVPFRLLG NIQVEEALLV FALPGSWIFL LFFARSAKLT GPFVQMIYSM IAGDMIRFAI
ISAIFLVSFS QVFYFLGKDM HAKQLLSPEN PDYCAVSGYA IFTYSSFLET FITLFRASMG
GYDYEEFACA NYEALTKILF VLYMFIMPIM MINILIAMMG NTYTTVIAQA EKAWRQQYAQ
IVMVLERSVR KEKLAACQLE YSIRLNETND AGMEIRGLMV IKQTKKTRAR QRKQAITNWK
TIGRKVIHTV DRLGVDHAKE LLHSHDRLID EPAVLLRRAD TAMPPTRGRM RSQMSTDAPP
EETRMKTVEV PRRESKTGMS PAEKEAREMS VSGPESIKSD STGPEYMIVA TTTNTSMTVE
RATGRRIVRG ADVLSSLEMP NMPSVGTPPP RQFSPRIRSD MFRRKDSPGT DSSSTHSNKQ
WNFDGSGAEE DNTVKNVSID MSETV
//
