ID A0A0B2USN0_TOXCA Unreviewed; 595 AA.
AC A0A0B2USN0;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) {ECO:0000313|WBParaSite:TCNE_0001375601-mRNA-1};
DE SubName: Full=Phosphoglucomutase-2 {ECO:0000313|EMBL:KHN72132.1};
GN Name=PGM2 {ECO:0000313|EMBL:KHN72132.1};
GN ORFNames=Tcan_16378 {ECO:0000313|EMBL:KHN72132.1}, TCNE_LOCUS13756
GN {ECO:0000313|EMBL:VDM45077.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN72132.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN72132.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN72132.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:TCNE_0001375601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDM45077.1, ECO:0000313|Proteomes:UP000267007}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the phosphohexose mutase family.
CC {ECO:0000256|ARBA:ARBA00010231, ECO:0000256|RuleBase:RU004326}.
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DR EMBL; JPKZ01003299; KHN72132.1; -; Genomic_DNA.
DR EMBL; UYWY01021881; VDM45077.1; -; Genomic_DNA.
DR STRING; 6265.A0A0B2USN0; -.
DR WBParaSite; TCNE_0001375601-mRNA-1; TCNE_0001375601-mRNA-1; TCNE_0001375601.
DR OMA; HVTKASY; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR Proteomes; UP000050794; Unplaced.
DR Proteomes; UP000267007; Unassembled WGS sequence.
DR GO; GO:0016868; F:intramolecular phosphotransferase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd05799; PGM2; 1.
DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 3.
DR Gene3D; 3.30.310.50; Alpha-D-phosphohexomutase, C-terminal domain; 1.
DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR InterPro; IPR005846; A-D-PHexomutase_a/b/a-III.
DR InterPro; IPR005843; A-D-PHexomutase_C.
DR InterPro; IPR036900; A-D-PHexomutase_C_sf.
DR InterPro; IPR016066; A-D-PHexomutase_CS.
DR InterPro; IPR005841; Alpha-D-phosphohexomutase_SF.
DR PANTHER; PTHR45745:SF1; PHOSPHOGLUCOMUTASE 2A-RELATED; 1.
DR PANTHER; PTHR45745; PHOSPHOMANNOMUTASE 45A; 1.
DR Pfam; PF02878; PGM_PMM_I; 1.
DR Pfam; PF02879; PGM_PMM_II; 1.
DR Pfam; PF02880; PGM_PMM_III; 1.
DR Pfam; PF00408; PGM_PMM_IV; 1.
DR PRINTS; PR00509; PGMPMM.
DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1.
DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 3.
DR PROSITE; PS00710; PGM_PMM; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU004326};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004326};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT DOMAIN 48..185
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
FT DOMAIN 220..320
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02879"
FT DOMAIN 359..450
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02880"
FT DOMAIN 523..570
FT /note="Alpha-D-phosphohexomutase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00408"
SQ SEQUENCE 595 AA; 66983 MW; F97F54EC58E61D08 CRC64;
MGASCADLDE LVANWLKWDK NEKNRKEIEE LVSKKDVETL KARMCKKMVF GTAGIRSRME
AGFSRLNDLT ILMVTNGFAL HLKEVYKRES NGVAIGYDGR HNSRRWAELA ANVFVRHGLK
VYLFSEVCPT PLVSYATIRL KCDAGLMITA SHNPKHDNGY KAYWSNGAQI LAPHDAEICR
IAYANMEPKP EFWDLSQLHS HPLLHSADPV IDDYFKDEQS LCHYKSINEK CPIKFTYSAF
HGVGLPYATR LFTNFGFSPD NISIVEEQAK PDPDFPTVPF PNPEEGRPVL KLSIETADRN
GATVILANDP DADRFQLAEK QPDGEWKVFA GNEMGALISW WTWKCWRKEN PEGDASNLYM
LNSAVSSSIV KTMAAKEGFK NELTLTGFKW MGNKADELRK QGKNVVLAWE ESIGFMAGHP
LDKDGITAAG IFAEIASYLH SENLTLAKQI FNIYKEYGFH VVRSSYWFVP NPDVTIKIFA
KLRKDNKYPV KIGDHSVKYV RDLTIGYDNE QPGNKPVLPL STSSEMITFT LADGSWATVR
ASGTEPKIKY YIELKTAPGK EEKDLVEVMA ELSKLEEMVV VNLLEPSVNG LIARK
//
