ID A0A0B2UZH6_TOXCA Unreviewed; 558 AA.
AC A0A0B2UZH6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=mbt {ECO:0000313|EMBL:KHN74614.1};
GN ORFNames=Tcan_03551 {ECO:0000313|EMBL:KHN74614.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN74614.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN74614.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN74614.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN74614.1}.
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DR EMBL; JPKZ01002894; KHN74614.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2UZH6; -.
DR STRING; 6265.A0A0B2UZH6; -.
DR OMA; FEHRYHA; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06648; STKc_PAK_II; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF4; SERINE_THREONINE-PROTEIN KINASE PAK MBT; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:KHN74614.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transferase {ECO:0000313|EMBL:KHN74614.1}.
FT DOMAIN 12..25
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 289..540
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 238..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 318
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 558 AA; 61354 MW; CCCCB8DF963DB3A2 CRC64;
MSMRKRPKKV EISAPMNFEH RIHAGFDPST GQYHGLPKQW QALMGTTLNR RGRPRPMVDP
SCITPLEMAE IKTIVRGDVP PRNVSGHVHG GIVSFGQQNS TLRSGMLPAS TQPVMHQSIR
IPENWTPVTS PSPSLSTLGS MQYHQRTRAP SGGLQRPNGC ITSLRGAPPG YDAALRASCR
SDSRQVTSFP ATDPAHGPLP NMDFSPRIST QLPTVNPHQC QLVPYCHSNA GATTSTVSSS
EAAAYRPSAG AMRPLPAASR DENKNRLSHD EFRAALKTVV LSGDPRADLA NFAQIGEGST
GIVMTANQIS TGRCVAVKRM NILKQQRREL LFNEVVIMRD YEHPNIVQMF GSYLIGDELW
VVMEYMEGGA LTDIITQTRM NEEMIATVCV QCLRALGYLH SKGVVHRDIK SDSILLARNG
VAKLSDFGFC GQLSADVPRR RSLVGTPYWM SPEVISRLPY GTEADIWSLG ILLIEMVQGE
PPLFDVQPLQ AMRTIRDMPP PTFSPSARVS PALESFLSRM LVRNASQRAT ASELLQDPFL
KIARQPSIIC SLMNLNHC
//
