ID   A0A0B2UZN2_TOXCA        Unreviewed;       843 AA.
AC   A0A0B2UZN2;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Complex I-49kD {ECO:0000256|ARBA:ARBA00030505};
DE   AltName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit {ECO:0000256|ARBA:ARBA00031562};
GN   Name=gas-1 {ECO:0000313|EMBL:KHN74669.1};
GN   ORFNames=Tcan_17687 {ECO:0000313|EMBL:KHN74669.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN74669.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN74669.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN74669.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00005769, ECO:0000256|RuleBase:RU003685}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN74669.1}.
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DR   EMBL; JPKZ01002876; KHN74669.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2UZN2; -.
DR   STRING; 6265.A0A0B2UZN2; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 4.
DR   HAMAP; MF_01358; NDH1_NuoD; 1.
DR   InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR   InterPro; IPR014029; NADH_UbQ_OxRdtase_49kDa_CS.
DR   InterPro; IPR022885; NDH1_su_D/H.
DR   InterPro; IPR029014; NiFe-Hase_large.
DR   PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1.
DR   Pfam; PF00346; Complex1_49kDa; 2.
DR   SUPFAM; SSF56762; HydB/Nqo4-like; 3.
DR   PROSITE; PS00535; COMPLEX1_49K; 2.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003685};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003685};
KW   Ubiquinone {ECO:0000313|EMBL:KHN74669.1}.
FT   DOMAIN          361..541
FT                   /note="NADH-quinone oxidoreductase subunit D"
FT                   /evidence="ECO:0000259|Pfam:PF00346"
FT   DOMAIN          573..843
FT                   /note="NADH-quinone oxidoreductase subunit D"
FT                   /evidence="ECO:0000259|Pfam:PF00346"
SQ   SEQUENCE   843 AA;  96146 MW;  86B322B851DF0506 CRC64;
     MASALNLRHL LCGAPRWRTL PALYNSSRGS HIWYPDAEFE RQFKKAGTLG TLSFSQATTD
     YDKQLGLDKF EKLMESQPVQ SDDYSGRHRE KSIENMILNF GPQHPAAHGV LRLVLKLEGE
     KAGTLGTLSF SQATTDYDKQ LGLDKFEKLM ESQPVQSDDY SGRHREKSIE NMILNFGPQH
     PAAHGVLRLV LKLEGEVIIK ATPHIGLLHR GTEKLIEYKT YTQALPYFDR LDYVSMMCNE
     SAFALATEKL LGINVPPRAK YIRKSEKRLV VRVIIKATPH IGLLHRGTEK LIEYKTYTQA
     LPYFDRLDYV SMMCNESAFA LATEKLLGIN VPPRAKYIRT LMYELTRLQN HIMGITTHAL
     DVGAMTPLFW MFEEREKLFE FTERASGARM HANYVRPGGV AWDLPLGWMD DVYDWCVKFP
     ERIDELDDML TENRIWKART IDVGIVSAGD ALNWGFTGVM VRGSGIKWDI RKAQPYDAYG
     ELEFDVPVGQ KGDCYDRYLC RMEEMRQSLH LVLQCLNNMP AGDVKVDDHK IVPPKRAEMK
     VSSLYGFLYD GALMYELTRL QNHIMGITTH ALDVGAMTPL FWMFEEREKL FEFTERASGA
     RMHANYVRPG GVAWDLPLGW MDDVYDWCVK FPERIDELDD MLTENRIWKA RTIDVGIVSA
     GDALNWGFTG VMVRGSGIKW DIRKAQPYDA YGELEFDVPV GQKGDCYDRY LCRMEEMRQS
     LHLVLQCLNN MPAGDVKVDD HKIVPPKRAE MKSSMEALIH HFIFFTDGFQ VPPGATYVPI
     EAPKGEFGVY LVADGTSKPY RCFIRAPGFV HLSKMHEICY MSLIADLVAV IGTLDLVFGE
     VDR
//