ID A0A0B2V0V9_TOXCA Unreviewed; 614 AA.
AC A0A0B2V0V9;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=IQ motif and SEC7 domain-containing protein 3 {ECO:0000313|EMBL:KHN75114.1};
GN Name=Iqsec3 {ECO:0000313|EMBL:KHN75114.1};
GN ORFNames=Tcan_09353 {ECO:0000313|EMBL:KHN75114.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN75114.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN75114.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN75114.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN75114.1}.
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DR EMBL; JPKZ01002781; KHN75114.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2V0V9; -.
DR STRING; 6265.A0A0B2V0V9; -.
DR OMA; VCYCRLN; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF342; FI21420P1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT DOMAIN 212..385
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 567..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 69341 MW; 4950D0FFA082D510 CRC64;
MSPASFPRRY AVPSNSSTLI TEWRTSASSS RMLSAYEISD DLSRRQIQVL ERRYGGRLRA
HAAATRIQRA FRQYRMMQQW RRLVVPLQHW NSGVTHIRCI ESVTRWRSGN VNAAQPQRIC
DASRYANASD SSLQQQQWSR RNCICSPSTQ VNPTNSIFRG TPLPNRTVAE PAAQAQSSSI
WVPRSSLSSA RSCHTNSLPR LDNHAAHSTS LRKPARGIQL LLNWGFVEES AHAVAKLLIG
RRGLSKQMIG EYLGHLHDPF HSSVLDHFIN EIDLHGMEID IALRHTLTFF RLPGEAQKIE
RIVQVFSRRY VACNPERAAS FHGADTVFVL AFAIIMLNTD LHSPNIKPSR KMKLDDFIKN
LRGIDAGFNI DRSLLTGVYE RIREHEFRSG SDHVTQVMKV DQSIVGKDKP KLVEPQRRLV
CYCRLNQIVD RSKRQAPNAH QREVFLFNDM LLMAKMLSKK KSCSQYTLRM WAALIGMRIR
VFETSLYRFG VSIFCQDGQE ILLNAKNDED RHRFVADVRE SIAECTEMEA IRIECELDRH
VGGGLSRSES QRDSGLPDYE GAPLGNDTCN GGAASSNGGS ERSRSTLLHT GRRLSFNSLD
SGVVEGAACE FVTS
//
