ID A0A0B2V3A5_TOXCA Unreviewed; 790 AA.
AC A0A0B2V3A5;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Plastin-2 {ECO:0000313|EMBL:KHN76033.1};
GN Name=Lcp1 {ECO:0000313|EMBL:KHN76033.1};
GN ORFNames=Tcan_16418 {ECO:0000313|EMBL:KHN76033.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN76033.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN76033.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN76033.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN76033.1}.
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DR EMBL; JPKZ01002583; KHN76033.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2V3A5; -.
DR STRING; 6265.A0A0B2V3A5; -.
DR OMA; NECIFAK; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:InterPro.
DR CDD; cd21298; CH_PLS_rpt3; 1.
DR CDD; cd21301; CH_PLS_rpt4; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961:SF18; FI19014P1; 1.
DR PANTHER; PTHR19961; FIMBRIN/PLASTIN; 1.
DR Pfam; PF00307; CH; 4.
DR SMART; SM00033; CH; 4.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS50021; CH; 4.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 188..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 267..388
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 416..521
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 539..647
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 661..768
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 217..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..248
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 88776 MW; 974E74B92B45C0AD CRC64;
MRCCAGDLPN CRLLGVVVMQ KPCRRSEQAE RPALLMFTKD QLADLAERFP TLNENGGGTI
ATAGVQEALR LTGIDLPGFQ IRDLLKRFGD AREVSFEEFQ QLFSELRTQK DQEVKKWKER
IGTVTGAYTV KGMSEHSNEE IVHTIRVEEE VAFSNWINSN LLGDADLKRL LPVKTDGGDL
YVKVQDGLIL WFVIFALFYN FSLCVVIVTW LAQCAKKKKP DPPEPVDSKT VLPAKLPPQP
PAKPSSSPSP DPKGDEKKDA KKEPAKEEKK EEKKEEKNGK TNGKKEGKEE GKKEANTDEK
KDEKKEDAKN AADESIKLIN LAVPETIDER AINKRNLNTY TKLENLTLAL MSAQAIGCNI
VNIDGDDLSK GKPHLVLGLL WQIIRIGLFN QIDLHHVPGL FRLLTEGETL DDLRRLSPEQ
ILIRWVNYHL EKAGIDRRLT NFTTDVVDSE IYTYLINEIA PSGSGVTLYP LSVQGNVARA
EAMLDEAEKL DCREFVTAND VAQGNYKLNL AFVANLFNKH PGLPDPNADE IVEEVVEETR
EEKTYRNWMN SMGVNPYVNW LYSDLTNGVI IFQLYDIIRP GMVNWKRVVQ KFSKLKGMMD
QIQNCNYAVE LGKQLRFSLV GIQGKDIYDG NQTLTLALVW QLMRAYTLTV LAQCTQSGDS
LATDREIIAW VNDKLSKRAK TSRIKSFQDP VISDARVVID LIDAIKPGII NYSLVRTGGI
EANMANAKYA ITSGRKIGAK IYALPEDIVE VKPRMVMTVF ACLMARDYMP NVWEEQLDSP
VTPMANNVSH
//
