ID   A0A0B2V9R3_TOXCA        Unreviewed;      1674 AA.
AC   A0A0B2V9R3;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012494};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
GN   Name=SHL2 {ECO:0000313|EMBL:KHN78229.1};
GN   ORFNames=Tcan_06342 {ECO:0000313|EMBL:KHN78229.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN78229.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN78229.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN78229.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517};
CC   -!- SIMILARITY: Belongs to the RdRP family.
CC       {ECO:0000256|ARBA:ARBA00005762}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN78229.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JPKZ01002145; KHN78229.1; -; Genomic_DNA.
DR   STRING; 6265.A0A0B2V9R3; -.
DR   OMA; HNEEPMD; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF59; RNA-DIRECTED RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 3.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000313|EMBL:KHN78229.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000313|EMBL:KHN78229.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ   SEQUENCE   1674 AA;  192852 MW;  79793B9BDDDC2AD5 CRC64;
     MDGDDRQLLP AKVILGEGGD KEVNFLKQRL PRIGISVPET IETHIAGIAA YEERHTELLF
     RVSKSSWEDS LLKMVTAFEI QCCSAWAPGS PGTPILQINH PGFFTRDCIP AHLSVPLRSV
     SFGNLINAGQ FLSHFTRHDD CEGPDALKWL CALRDEKIAH AMVADFEHDR SVMTVRFAVL
     DGGYKPKNNE KVNMDKRKYI PASAIALKMK YSSVRRIVVD LDIDCCMARI YFQLNFPVEI
     RKFRKKPFDP MMRDGDRHRS FPESAKDKRD NCVAINESPF ICLECKSLVA ESELYGILCR
     LHARIGLPLD FTRIHTKYIP VSKYVAPPVR MIRCDHHWSR TADGHADRNQ SAHSVELSVD
     ERCAAELKRR KNFGLEYFIA ALISRGAIVK DQILNCKENR DSFISMVLAH YDKDKENCKE
     NRDSFINMVL AHYDKDKEVT MEALERLLNM LDERREAPPL FRTFEDIRKG LIAESDQLKE
     IYAREETDGY RRVRKMVLTP TRMLLVVPEL LMGNRVLRTY DESGDYALRV QFRDDDGSRM
     KQNTNCKENR DSFINMVLAH YDKDKEVTME ALERLLNMLD ERREAPPLFR TFEDIRKGLI
     AESDQLKEIY AREETDGYRR VRKMVLTPTR MLLVVPELLM GNRVLRTYDE SGDYALRVQF
     RDDDGSRMKQ NTVGQYLINA TVHDTMERGV YIADRHFVYL ASSNSQMRDN GCYFFDDGDG
     GRAQQIRKDL GVFDRSNIPK LMARMGQCFT QAKQCSAKLR HKRYNKTFDL IGGRDTSGEP
     YIFSDGCGRM SQEFARKIAN DLDIGKCVPS CFQDKFHAPL SNTIEIVKYS SPTPVCLNRP
     FIAILDQVSG MQGYQAHTRI CERICLLLDR QLMQMAETLM SEDKCRDRLR ELPRRVNVDE
     LSLARGFALT QEPFFRSLLR ASVAYTIKKQ LTKAQIQIPP HLGRTLFGIV DETGILQYGQ
     VFVQYTNAVE NKTPGPSAAK TILKGRVLMT KNPQIVAGDA RVFNAIDVPE LRHLVDVVVF
     PQYGPRPHSD EMSGSDLDGD EYCVIWDEQL MLDYNEEASD FTKQSREPDD VSDDEVVPAM
     LKFFVDYIKQ DSIGTIANAF MVNADLYGIT SAVCLNIAQK QSQSVDFPKT GQPPEPLVKV
     WTENEDGSFL PPERAERWPD FMNKPYEPSY VSPRLLGHLF RRTRLVEDVL TITTAYEERD
     AVSLDIDLLY PRREEYYEDA KAEFNTYSAD VRALLDNYGV QDEGQLFSGC ISVLRNRISD
     RDMDDMSVYN TNHMIERKLN DIFLRFRENF FEEFGGYWEN TDPEYGSSNN EGLQDDQRRI
     CTNPSSAMKM KASAYYEICY TEASSNTSSK RLLSFPWVVW DVLACIKQNA KTRIISIDPL
     NECLSEAINR FCEKNSGVEN FMQEITRHSS SAHAIRRYCR RYKGLDKLMF VAWKWAEQQE
     LFEGRLNAQH LCLLFIQFGL GYLSAEDVSR PFSFLEKTDD LMDEHSPNVI DLNDRLGGLG
     KCFIKFLQFL SSRSFETIKM INFMRPNLGY HSVLMRGQWL DLHKAAVKSF YRIVLTGRFE
     ELSYACDSSA RRSHDAYLRE IEPFVVELPE DRRGEDEQIR RKMQIHSGVK YLQLRRIANF
     RNRVVVSAVG TMESLHRLRN ILAVKPSLNS YANNKSRSEM ISRLVYERIS LMAV
//