ID A0A0B2VAC1_TOXCA Unreviewed; 977 AA.
AC A0A0B2VAC1;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Nuclear hormone receptor family member nhr-5 {ECO:0000313|EMBL:KHN78407.1};
GN Name=nhr-5 {ECO:0000313|EMBL:KHN78407.1};
GN ORFNames=Tcan_02875 {ECO:0000313|EMBL:KHN78407.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN78407.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN78407.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN78407.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Orphan nuclear receptor. {ECO:0000256|ARBA:ARBA00037512}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|ARBA:ARBA00005993}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN78407.1}.
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DR EMBL; JPKZ01002099; KHN78407.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VAC1; -.
DR STRING; 6265.A0A0B2VAC1; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06960; NR_DBD_HNF4A; 1.
DR CDD; cd06157; NR_LBD; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 2.
DR InterPro; IPR049636; HNF4-like_DBD.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR47519; NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED; 1.
DR PANTHER; PTHR47519:SF3; NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-5; 1.
DR Pfam; PF00104; Hormone_recep; 2.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 2.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 2.
DR PROSITE; PS51843; NR_LBD; 2.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KHN78407.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 87..162
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 205..473
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT DOMAIN 485..649
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 66..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 109809 MW; 16A4E05E52BB917B CRC64;
MNNSCSQACT SSSIFTSASD CESSSAVDQR QTFKPIDYES KPEICYETSL PRISSQNLLS
EEDAPLEVAS TEDTTRDDSP TSGVATGETC RVCGDAQAKM HYGVLACFGC KGFFRRALKR
ANQYECNNNR KCVIDKFERN SCRYCRLQRC LEVGMDPAAV RPDRDFTGPQ HAVRLPVVKR
PIKEESRDQG VSNESSEWTK RLPVEMRTML MTLLNIEAKV TKGDTKRKAE EVYPLPEHTL
RELIEDPSKL KGLRTEMRYE PYRMAANSEL LLIAYRRLIA AVDWVTYLSE MIDGITLDDK
IALVKNCFAP LLVFTFAVRT AEVTDDPDVL CLCTFSFVPR NMAKAYTDSY HLSNGLVERA
LNELVMPLRN LKLKQEEIVC LNATIVLNPH TKDLSPEGSQ KVIELRSRIQ DTLYHFIKET
RSKDRASVQF GNLLLFLPNV TLIANSMSEN LQFAQTFSPF GGIPLLTNLF GCFPVEPFND
IPMDATESNP SMELDDEGSD VDVFNKEPAT FVDAAVQTDN FINEEVHLSN GLVERALNEL
VMPLRNLKLK QEEIVCLNAT IVLNPHTKDL SPEGSQKVIE LRSRIQDTLY HFIKETRSKD
RASVQFGNLL LFLPNVTLIA NSMSENLQFA QTFSPFGGIP LLTNLFGCFP VEPFNDIPMD
ATESNPSMEL DDEGSDVDVF NKEPATFVDA AVQTDNFINE EKTQKRRRVE PSLLSPIENP
ESRDFQLLQP PCVYTLTEMF DDANTDTRDQ FVAQMKDQKA LLESSAIALA SSSLYEQQHP
SGSDEWKDFV MPSSGSQPRR YSYSGNAFTN NDVSMYRHRR TLNMKRMQSS ATLEPSVSAN
SSQPKFTLDI ATSPAFAYTS SSALPRSDSV NIPFPGNLNE FLCPRPDVKR NPMLHNMRQS
VSAKPPISRT YETTFTNVDY IDTPQVGVET KSAIAVSYGI QPCFTLSNSF DNFMEPNTNI
FSLNNPRSLN AETAFRL
//
