ID A0A0B2VB23_TOXCA Unreviewed; 235 AA.
AC A0A0B2VB23;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Apoptosis regulator ced-9 {ECO:0000313|EMBL:KHN78669.1};
GN Name=ced-9 {ECO:0000313|EMBL:KHN78669.1};
GN ORFNames=Tcan_09290 {ECO:0000313|EMBL:KHN78669.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN78669.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN78669.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN78669.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN78669.1}.
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DR EMBL; JPKZ01002071; KHN78669.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VB23; -.
DR STRING; 6265.A0A0B2VB23; -.
DR OMA; KEHNRSW; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-UniRule.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR003093; Bcl2_BH4.
DR PANTHER; PTHR11256:SF50; APOPTOSIS REGULATOR CED-9; 1.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR Pfam; PF02180; BH4; 1.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
DR PROSITE; PS50063; BH4_2; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PROSITE-
KW ProRule:PRU00025};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 210..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..56
FT /note="Apoptosis regulator Bcl-2 family BH4"
FT /evidence="ECO:0000259|PROSITE:PS50063"
FT MOTIF 37..56
FT /note="BH4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00025"
SQ SEQUENCE 235 AA; 27337 MW; 707B42CBB5422735 CRC64;
MEGTQSTSDV SHIGSESSAE IVDVEPLRDF EHDKYAIQGF VVDYFTYRLQ LKDFEWAERP
VLPYENLAEY EAMRDVALIF ERRHSDELNR MVDQLLSDKY LSFQRYVEVV ENFGRNDDES
PAHMSYGRLV ALISFGGVMV CRLAEEHMRS EISAVALYTS KFLEKRIQLS WAQDDRSWAK
FVECAEMIKR RDSVRQRERE ECARARVRRW SWIGLATVGV VGIGAFTLTR AVLSR
//
