ID A0A0B2VC95_TOXCA Unreviewed; 1058 AA.
AC A0A0B2VC95;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Sodium-driven chloride bicarbonate exchanger {ECO:0000313|EMBL:KHN79123.1};
GN Name=SLC4A10 {ECO:0000313|EMBL:KHN79123.1};
GN ORFNames=Tcan_14474 {ECO:0000313|EMBL:KHN79123.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN79123.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN79123.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN79123.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN79123.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPKZ01001947; KHN79123.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VC95; -.
DR STRING; 6265.A0A0B2VC95; -.
DR OMA; CALDRTH; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF47; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 2.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 446..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 806..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 927..951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..285
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 296..360
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 415..744
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
SQ SEQUENCE 1058 AA; 120043 MW; 31702EA2EB958AEF CRC64;
MGLQMEDDEH KDRQLLIQFD ELLMKCESRD GGEEWRQLGR WIRYEEAVEV GAQRFGKPKL
SSLSFHALLQ LRHCFEIGAV MLDLNLDRHE NLFEGIVEEM LRTNTLHSSD RDHLLRLLRL
PRRHTFQQSA ISSGGTLRSL RRYFGIGLTA DTNSNSVMRL QNGHNASSKR GSAKRRRSVF
PWERNPWNTE LLKRLSLDAE AASVGVGTSA RLRHMCVAFV RLRPGTYVEN QVELPLPLRY
FFVILGPITP NLDFHEIGRS LCTLLANRRF RDACSCALDR THLIQLKVLD QETIKKYFFV
ILGPITPNLD FHEIGRSLCT LLANRRFRDA CSCALDRTHL IQAINDFLDE SMVVPPGDWE
LDKLADHDFE RAHRVRHRLG PRRRALASRP IELDQYLIDE EKRKRNDPLR RTGALFGGLR
REMRKRFPHY LSDLRDAFNL QCVRCVIFIF LTCFFPALTF GAILGEITNG EMGMTETLLA
TSVGGITFAF LSTQPLIVIG VVGSMLIFEE SLYMFSSVNG FPYLAMRFWV SIWALLFAAV
VVCFEGSLLI RNVTRFSDDI LSALISVIFF SECIRFLWTI FNDNPLMTAE QYCNASLTDE
LHRNDSTASR TPHGQPNTAL LASFFTAATF LVAFALRRVR NSRYFGRQVR RALGDFGLSI
SVILMVLLDK VLISASSLTS TLNIRIEILP SVERNWLVEV LEWPSERTPL PVAAVLPGFL
LFFLLFTETL VCEAMLLSPE LKVRRALGDF GLSISVILMV LLDKVLISAS SLTSTLNIRI
EILPSVERNW LVEVLEWPSE RTPLPVAAVL PGFLLFFLLF TETLVCEAML LSPELKVKKG
TGYHFDLLLS GILLVANALF GLPWLCAASM RTTAHVHSLT LYKLRAPGQK PRIVGLREQR
LTAVALHALI GSTLLFPDVL KSIPQSVLFG VFLYLGVMNL TSSQMLSRSI LFFVPVKYHP
CVTYCLRVRT WRMHAFTTIQ LLCFVVVCFI KSHKSTAFAF PLAILMAVGV RQLLLPRLFT
SMELLALDGV DEEPQQDGDF YEDSRAPALL SSFYVDET
//