ID A0A0B2VHC6_TOXCA Unreviewed; 261 AA.
AC A0A0B2VHC6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Transcription factor E2F4 {ECO:0000313|EMBL:KHN82926.1};
GN Name=E2F4 {ECO:0000313|EMBL:KHN82926.1};
GN ORFNames=Tcan_14226 {ECO:0000313|EMBL:KHN82926.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN82926.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN82926.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN82926.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN82926.1}.
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DR EMBL; JPKZ01001280; KHN82926.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VHC6; -.
DR STRING; 6265.A0A0B2VHC6; -.
DR OMA; FDMQYNL; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF18; TRANSCRIPTION FACTOR E2F2; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 1..40
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
SQ SEQUENCE 261 AA; 30321 MW; 9C5DC0BAFD0ED25A CRC64;
MKAAEDLNVR QKRRIYDITN VLEGVGLIEK KSKNIIQWKG GELRKPGVRE LKPEEEERLF
KLKLELTEQE REERLLDTHL KWLRQSIRNV SEYHLNQKLA YSTQDDLIEV FPESTVLVIQ
APPGTCLEVQ HSPKLRDMDL RYQMHLRSPY GPAGVLLINK DEKLRSQFAH LSGRFQPLFK
SAYATVGDEP GQILEDEDDE GFVKRRRVDE DLNNPNAVLP RFPSQVQDVL QRLSPPPSEH
DYIFNLNQGE SLTDLFHDDT I
//
